Three‐dimensional collagenous niche and azacytidine selectively promote time‐dependent cardiomyogenesis from human bone marrow‐derived MSC spheroids
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26714
Abstract: Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure‐function‐mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate… read more here.
Keywords: cell; cardiomyogenesis human; time dependent; msc spheroids ... See more keywords
Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120607
Abstract: Mesenchymal stromal cells (MSCs) can promote tissue repair in regenerative medicine, and their therapeutic potential is further enhanced via spheroid formation. Stress relaxation of hydrogels has emerged as a potent stimulus to enhance MSC spreading… read more here.
Keywords: bone formation; msc spheroids; mechanics; formation ... See more keywords
Cell spheroids are as effective as single cells suspensions in the treatment of critical-sized bone defects
Sign Up to like & getrecommendations! Published in 2021 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-021-04264-y
Abstract: Background Due to their multilineage potential and high proliferation rate, mesenchymal stem cells (MSC) indicate a sufficient alternative in regenerative medicine. In comparison to the commonly used 2-dimensional culturing method, culturing cells as spheroids stimulates… read more here.
Keywords: critical sized; msc suspensions; msc spheroids; bone ... See more keywords