In Vivo Nonlinear Light Scattering Probe of Drug-Induced Activation of Bacterial Mechanosensitive Channels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.3125
Abstract: The lack of homologues of the mechanosensitive (MS) channel of large conductance (MscL) in the human genome makes it a novel antimicrobial target. Specifically, MscL activators have been proposed as potential antibacterial species as they… read more here.
Keywords: transport; drug induced; mscl; light scattering ... See more keywords
Approaches for the modulation of mechanosensitive MscL channel pores
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1162412
Abstract: MscL was the first mechanosensitive ion channel identified in bacteria. The channel opens its large pore when the turgor pressure of the cytoplasm increases close to the lytic limit of the cellular membrane. Despite their… read more here.
Keywords: modulation; mscl; mechanosensitive mscl; modulation mechanosensitive ... See more keywords
In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL
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DOI: 10.3390/antibiotics11040433
Abstract: MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress. It opens… read more here.
Keywords: mscl; mechanosensitive channel; silico screen; channel ... See more keywords
Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11070970
Abstract: Resistance to antibiotics is a serious and worsening threat to human health worldwide, and there is an urgent need to develop new antibiotics that can avert it. One possible solution is the development of compounds… read more here.
Keywords: bacterial mechanosensitive; membrane permeabilization; mscl; resistance ... See more keywords