Elucidating the molecular basis of MSH2‐deficient tumors by combined germline and somatic analysis
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DOI: 10.1002/ijc.30820
Abstract: In a proportion of patients presenting mismatch repair (MMR)‐deficient tumors, no germline MMR mutations are identified, the so‐called Lynch‐like syndrome (LLS). Recently, MMR‐deficient tumors have been associated with germline mutations in POLE and MUTYH or… read more here.
Keywords: deficient; msh2; deficient tumors; analysis ... See more keywords
Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk
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DOI: 10.1016/j.ajhg.2020.12.003
Abstract: Summary The lack of functional evidence for the majority of missense variants limits their clinical interpretability and poses a key barrier to the broad utility of carrier screening. In Lynch syndrome (LS), one of the… read more here.
Keywords: missense variants; massively parallel; msh2; parallel functional ... See more keywords
Analysis of the Expression and Prognostic Value of MSH2 in Pan-Cancer Based on Bioinformatics
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DOI: 10.1155/2021/9485273
Abstract: Background MutS homolog 2 (MSH2), with the function of identifying mismatches and participating in DNA repair, is the “housekeeping gene” in the mismatch repair (MMR) system. MSH2 deficiency has been reported to enhance cancer susceptibility… read more here.
Keywords: cancer; expression; msh2; msh2 pan ... See more keywords
A Pan-Cancer Analysis on the Systematic Correlation of MutS Homolog 2 (MSH2) to a Malignant Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/9175402
Abstract: MutS homolog 2 (MSH2) is a crucial participant in human DNA repair, and lots of the studies functionally associated with it were begun with hereditary nonpolyposis colorectal cancer (HNPCC). MSH2 has also been reported to… read more here.
Keywords: msh2; expression; analysis; muts homolog ... See more keywords
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2072
Abstract: Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in… read more here.
Keywords: cell adhesion; msh2; chromatin; bet inhibition ... See more keywords
MEX3A impairs DNA mismatch repair signaling and mediates acquired temozolomide resistance in glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2036
Abstract: MutS protein homolog 2 (MSH2) is a key element involved in the DNA mismatch repair system, which is responsible for recognizing and repairing mispaired bases. Simultaneously, MSH2 identifies DNA adducts induced by temozolomide (TMZ) and… read more here.
Keywords: mismatch repair; dna mismatch; msh2; mex3a ... See more keywords
Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1186/s13148-019-0639-8
Abstract: BackgroundMismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 methylation profiles in… read more here.
Keywords: genome wide; msh2; single radiation; msh2 mice ... See more keywords
Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.627460
Abstract: Background A large proportion of patients with Lynch syndrome (LS) have MSH2 abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking. The aim of this study was to comprehensively analyze the clinicopathological… read more here.
Keywords: msh2; cytoplasmic msh2; colorectal cancer; crc patients ... See more keywords
Lynch Syndrome-Associated Endometrial Cancer With Combined EPCAM-MSH2 Deletion: A Case Report
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.856452
Abstract: Background Lynch syndrome (LS), an autosomal dominant disorder, is characterized by germline pathogenic variants in DNA mismatch repair (MMR) genes like MSH2. EPCAM deletions cause a minority (3%) of LS cases. However, there are only… read more here.
Keywords: endometrial cancer; msh2; lynch syndrome; case ... See more keywords
MSH2 Overexpression Due to an Unclassified Variant in 3’-Untranslated Region in a Patient with Colon Cancer
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DOI: 10.3390/biomedicines8060167
Abstract: Background: The loss or low expression of DNA mismatch repair (MMR) genes can result in genomic instability and tumorigenesis. One such gene, MSH2, is mutated or rearranged in Lynch syndrome (LS), which is characterized by… read more here.
Keywords: variant untranslated; msh2; cancer; gene ... See more keywords
Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14050952
Abstract: As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins. We have described that the replication and transcription machinery of Andrias davidianus ranavirus (ADRV) which… read more here.
Keywords: transcription; andrias davidianus; replication; msh2 ... See more keywords