Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine
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DOI: 10.1186/s13148-019-0639-8
Abstract: BackgroundMismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 methylation profiles in… read more here.
Keywords: genome wide; msh2; single radiation; msh2 mice ... See more keywords