Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab102
Abstract: In the baker's yeast Saccharomyces cerevisiae, most of the meiotic crossovers are generated through a pathway involving the highly conserved mismatch repair related Msh4-Msh5 complex. To understand the role of Msh4-Msh5 in meiotic crossing over,… read more here.
Keywords: crossover; msh5; yeast; msh5 association ... See more keywords
The Msh5 complex shows homeostatic localization in response to DNA double-strand breaks in yeast meiosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1170689
Abstract: Meiotic crossing over is essential for the segregation of homologous chromosomes. The formation and distribution of meiotic crossovers (COs), which are initiated by the formation of double-strand break (DSB), are tightly regulated to ensure at… read more here.
Keywords: localization; double strand; msh5; reduced dsbs ... See more keywords
A Homozygous Loss-of-Function Mutation in MSH5 Abolishes MutSĪ³ Axial Loading and Causes Meiotic Arrest in NOA-Affected Individuals
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126522
Abstract: Non-obstructive azoospermia (NOA), characterized by spermatogenesis failure and the absence of sperm in ejaculation, is the most severe form of male infertility. However, the etiology and pathology between meiosis-associated monogenic alterations and human NOA remain… read more here.
Keywords: loss function; noa; function mutation; msh5 ... See more keywords