Establishment of a gastric cancer cell line with high microsatellite instability, OCUM‐13, derived from Borrmann type‐2 primary tumor
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5403
Abstract: Gastric cancer (GC) with microsatellite instability (MSI) has been reported to be sensitive to immunotherapy, however some of GC cases with MSI remain resistant to immunotherapy. Cancer cell lines showing MSI might be useful for… read more here.
Keywords: cell; cell line; msi; tumor ... See more keywords
Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33322
Abstract: Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI‐H), low MSI (MSI‐L) and microsatellite stable (MSS). MSI‐H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment… read more here.
Keywords: msi; msi tumors; mss; microsatellite instability ... See more keywords
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohorts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34119
Abstract: Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system and strongly correlates with high tumor mutation burden (TMB).… read more here.
Keywords: msi; microsatellite instability; genomic landscape; instability ... See more keywords
Noninvasive detection of microsatellite instability in patients with endometrial cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34435
Abstract: The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating‐DNA (cfDNA) samples capture the intratumor… read more here.
Keywords: endometrial cancer; microsatellite instability; analysis; msi ... See more keywords
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue.
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202100223
Abstract: MALDI MS imaging (MSI) is a powerful analytical tool for spatial peptide detection in heterogeneous tissues. Proper sample preparation is crucial to achieve high quality, reproducible measurements. Here we developed an optimized protocol for spatially… read more here.
Keywords: tissue; msi; detection; protocol ... See more keywords
Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1216-2
Abstract: AbstractMass spectrometry imaging (MSI) has provided many results with translational character, which still have to be proven robust in large patient cohorts and across different centers. Although formalin-fixed paraffin-embedded (FFPE) specimens are most common in… read more here.
Keywords: fixed paraffin; msi; paraffin embedded; study ... See more keywords
Comprehensive clinicopathologic, molecular, and immunologic characterization of colorectal carcinomas with loss of three intestinal markers, CDX2, SATB2, and KRT20
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-021-03260-w
Abstract: Caudal-type homeobox 2 (CDX2), special AT-rich sequence-binding protein 2 (SATB2), and keratin 20 (KRT20) are frequently used as intestinal epithelium-specific markers in immunohistochemical studies. However, subsets of colorectal carcinomas (CRCs) show loss of these markers.… read more here.
Keywords: expression; satb2 krt20; msi; loss ... See more keywords
Comparison of the Idylla™ MSI assay with the Promega™ MSI Analysis System and immunohistochemistry on formalin-fixed paraffin-embedded tissue of endometrial carcinoma: results from an international, multicenter study
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-022-03291-x
Abstract: Determination of microsatellite instability (MSI) and mismatch repair deficiency (MMRD), respectively, in endometrial carcinomas (ECs) is important for diagnostic and prognostic purposes, identification of Lynch syndrome carriers, and selection of patients for immunotherapy. The Idylla™… read more here.
Keywords: idylla msi; system; promega msi; msi assay ... See more keywords
Towards enhanced metabolomic data analysis of mass spectrometry image: Multivariate Curve Resolution and Machine Learning.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.02.031
Abstract: Large amounts of data are generally produced from mass spectrometry imaging (MSI) experiments in obtaining the molecular and spatial information of biological samples. Traditionally, MS images are constructed using manually selected ions, and it is… read more here.
Keywords: data analysis; msi; analysis; multivariate curve ... See more keywords
High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.339085
Abstract: Simultaneous spatial localization and structural characterization of molecules in complex biological samples currently represents an analytical challenge for mass spectrometry imaging (MSI) techniques. In this study, we describe a novel experimental platform, which substantially expands… read more here.
Keywords: resolution; high resolution; nano desi; msi ... See more keywords
Inactivating frameshift mutation of putative tumor suppressor genes PLA2R1 and SRPK1 in gastric and colorectal cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2016.11.005
Abstract: To the Editor: Phospholipase A2 receptor 1 (PLA2R1) encodes a transmembrane receptor that plays a role in clearance of phospholipase A2, thereby inhibiting the action of phospholipaseA2 (1). Activation of PLAR1 leads to cellular senescence,… read more here.
Keywords: pla2r1 srpk1; msi; frameshift mutations; cancer ... See more keywords