Current Microsatellite Instability Testing in Management of Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical colorectal cancer"
DOI: 10.1016/j.clcc.2020.08.001
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. In the past decade, mismatch repair deficiency (dMMR), manifested as microsatellite instability-high (MSI-H), has been recognized as a distinct mechanism promoting tumorigenesis in 15% of… read more here.
Keywords: management; msi crcs; colorectal cancer; crcs ... See more keywords
Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003414
Abstract: Background Colorectal cancers (CRCs) with microsatellite instability-high (MSI-H) are hypermutated tumors and are generally regarded as immunogenic. However, their heterogeneous immune responses and underlying molecular characteristics remain largely unexplained. Methods We conducted a retrospective analysis… read more here.
Keywords: msi crcs; immune low; immune; heterogeneous immune ... See more keywords