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   Articles with "msi dmmr" as a keyword



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Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status

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recommendations! Published in 2018 at "JAMA Oncology"

DOI: 10.1001/jamaoncol.2018.4942

Abstract: Importance Primary resistance to immune checkpoint inhibitors is observed in 10% to 40% of patients with metastatic colorectal cancer (mCRC) displaying microsatellite instability (MSI) or defective mismatch repair (dMMR). Objective To investigate possible mechanisms underlying… read more here.

Keywords: status; immune checkpoint; checkpoint inhibitors; dmmr ... See more keywords
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Patients atteints d’un cancer gastrique localisé MSI/dMMR, pas de chimiothérapie mais une immunothérapie périopératoire : l’essai de phase II GERCOR NEONIPIGA vient d’être ouvert au recrutement

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recommendations! Published in 2020 at "Bulletin Du Cancer"

DOI: 10.1016/j.bulcan.2019.11.016

Abstract: Resume Introduction La chimiotherapie perioperatoire est la strategie de reference pour les cancers gastriques (CG) localises, mais semble inefficace voire deletere pour les patients avec un cancer MSI/dMMR (microsatellites instables/MMR-deficient), biomarqueur predictif de l’efficacite de… read more here.

Keywords: pour les; dmmr; gercor neonipiga; msi dmmr ... See more keywords
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Detecting immunotherapy-sensitive subtype in gastric cancer using histologic image-based deep learning

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-02168-4

Abstract: Immune checkpoint inhibitor (ICI) therapy is widely used but effective only in a subset of gastric cancers. Epstein–Barr virus (EBV)-positive and microsatellite instability (MSI) / mismatch repair deficient (dMMR) tumors have been reported to be… read more here.

Keywords: msi; ebv msi; dmmr; deep learning ... See more keywords
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Cost-effectiveness of Pembrolizumab for the first-line treatment of patients with unresectable or metastatic MSI-H/dMMR colorectal cancer in the United States.

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recommendations! Published in 2022 at "Journal of medical economics"

DOI: 10.1080/13696998.2022.2043634

Abstract: AIMS Approximately 4% of Stage IV colorectal cancers (CRC) are microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) tumors. Patients with metastatic MSI-H/dMMR CRC receiving conventional therapies experience lower response rates and tend to have worse overall… read more here.

Keywords: msi dmmr; treatment; pembrolizumab; first line ... See more keywords
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Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications

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recommendations! Published in 2020 at "Gut"

DOI: 10.1136/gutjnl-2020-320726

Abstract: Objective Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) have gained considerable interest due to the success of immunotherapy in this molecular setting. Here, we aim to clarify clinical-pathological and/or molecular features of… read more here.

Keywords: msi dmmr; pathology; pdac; histology ... See more keywords
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Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence: Results of an accent meta-analysis of seven studies.

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recommendations! Published in 2019 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2019.37.15_suppl.3525

Abstract: 3525 Background: Microsatellite instable/deficient mismatch repair (MSI) metastatic colorectal cancers have been reported to be of poor prognosis. The interaction between MSI and BRAFV600E mutation complicates the picture. Methods: Patients with resected stage III CC… read more here.

Keywords: msi dmmr; stage iii; recurrence; mismatch repair ... See more keywords
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Pembrolizumab in Patients With Microsatellite Instability–High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study

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recommendations! Published in 2022 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.21.01874

Abstract: PURPOSE Pembrolizumab demonstrated durable antitumor activity in patients with previously treated, advanced microsatellite instability–high or mismatch repair–deficient (MSI-H/dMMR) tumors, including endometrial cancer, in the nonrandomized, open-label, multicohort, phase II KEYNOTE-158 study (NCT02628067). We report efficacy… read more here.

Keywords: keynote 158; endometrial cancer; msi dmmr; microsatellite instability ... See more keywords
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Immunotherapy for Early Stage Colorectal Cancer: A Glance into the Future

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recommendations! Published in 2020 at "Cancers"

DOI: 10.3390/cancers12071990

Abstract: Immune checkpoint inhibitors (ICI) have reshaped therapeutic strategies for cancer patients. The development of ICI for early stage colorectal cancer is accompanied by specific challenges: (i) the selection of patients who are likely to benefit… read more here.

Keywords: stage colorectal; colorectal cancer; msi dmmr; early stage ... See more keywords