[Best supportive care in a young patient with locally advanced MSI-high colon cancer?]
Sign Up to like & getrecommendations! Published in 2020 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1174-0732
Abstract: Molecular diagnostics are increasingly important to guide treatment decisions in oncologic patients. For instance, the presence of high-grade microsatellite-instability (MSI-high) is considered to be one of the major positive predictors of therapy response to immune-checkpoint… read more here.
Keywords: supportive care; young patient; cancer; msi high ... See more keywords
O09 Microsatellite-unstable sporadic sebaceous and duodenal tumours are associated with loss of mismatch protein expression
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljae105.009
Abstract: Lynch syndrome (LS) is a common heritable cancer predisposition syndrome. Tumours from patients with LS demonstrate microsatellite instability (MSI-high), a genetic signature detectable by low-cost DNA sequencing assays that is currently utilized in colorectal cancer… read more here.
Keywords: loss; mmr; msi high; protein ... See more keywords
Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0174
Abstract: In patients with colorectal cancer, the presence of Fusobacterium nucleatum may suppress immune responses for microsatellite instability (MSI)-high tumors and encourage immune responses for non-MSI-high tumors. F. nucleatum and MSI status interact to affect antitumor… read more here.
Keywords: status; nucleatum; msi status; cancer ... See more keywords
Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000494406
Abstract: Background: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor. Summary: Previously published studies analyzing the trend… read more here.
Keywords: surgically resected; status; egj adenocarcinoma; trend ... See more keywords
Immunohistochemical Analysis of Mismatch Repair Gene Proteins in Early Gastric Cancer Based on Microsatellite Status
Sign Up to like & getrecommendations! Published in 2020 at "Digestion"
DOI: 10.1159/000510679
Abstract: Background: Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis and is observed in 10–20% of early gastric cancers (EGCs). Early detection of EGCs with an MSI-high phenotype would be useful for elucidating… read more here.
Keywords: mlh1; loss; mismatch repair; expression ... See more keywords
Molecular and clinical determinants of targeted therapy (TT) outcomes in biliary tract cancer (BTC): Analysis of a prospectively maintained next generation sequencing (NGS) biorepository.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.4_suppl.555
Abstract: 555 Background: BTCs are genomically diverse. TT have established antitumor activity in a subset of pts that harbour actionable alterations; however, most patients (pts) do not respond to or experience acquired resistance on TT. We… read more here.
Keywords: cancer; resistance; msi high; therapy outcomes ... See more keywords
Prognostic and predictive value of microsatellite instability status among patients with colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of comparative effectiveness research"
DOI: 10.2217/cer-2021-0013
Abstract: Objectives: Compare overall survival (OS) between microsatellite instability (MSI) high and MSI-stable and analyze the effect of chemotherapy on OS. Methods: National cancer database was queried for patients diagnosed with colorectal adenocarcinoma between 2010 and… read more here.
Keywords: cancer; msi high; colorectal cancer; microsatellite instability ... See more keywords
EBV and MSI Status in Gastric Cancer: Does It Matter?
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010074
Abstract: Simple Summary Gastric cancer is characterized by high morphologic and molecular heterogeneity. Microsatellite instability (MSI-high) and Epstein–Barr-virus-positive (EBV+) tumors have been associated with better prognosis, but the benefit of perioperative chemotherapy (POPChT) in these tumors… read more here.
Keywords: msi high; ebv; status; gastric cancer ... See more keywords
Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancers"
DOI: 10.3390/cancers16112005
Abstract: Simple Summary Microsatellite instability (MSI) is a hallmark of colorectal cancer (CRC) that is present in 10–15% of all patients with this condition. MSI results from the inactivation of the mismatch repair (MMR) pathway in… read more here.
Keywords: colorectal cancer; msi high; msi; microsatellite instability ... See more keywords
Comparison of Mismatch Repair Status Between Primary and Matched Metastatic Sites in Patients With Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the National Comprehensive Cancer Network : JNCCN"
DOI: 10.6004/jnccn.2019.7308
Abstract: BACKGROUND Differences between the features of primary cancer and matched metastatic cancer have recently drawn attention in research. This study investigated the concordance in microsatellite instability (MSI) and mismatch repair (MMR) status between primary and… read more here.
Keywords: status; matched metastatic; status primary; metastatic tumors ... See more keywords