An innovative single‐base extension method for synchronous detection of point mutations and MSI status in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5557
Abstract: An accurate genotyping analysis is one of the critical prerequisites for patients with colorectal cancer receiving matched therapies. Conventional genotyping analysis is currently used to detect either gene mutations or MSI status, delaying the detection… read more here.
Keywords: msi status; detection; colorectal cancer; mutations msi ... See more keywords
MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2022-208143
Abstract: Aims Mucinous adenocarcinoma (MA) is associated with a high frequency of microsatellite instability (MSI). In the metastatic setting, it is crucial to establish mismatch repair (MMR) and/or MSI status. However, genetic heterogeneity between primary tumour… read more here.
Keywords: synchronous metastasis; msi status; mmr msi; status ... See more keywords
Abstract 4205: Direct measurement of TA repeat expansions significantly outperforms MSI-H status as a predictor of sensitivity to the novel WRN inhibitor MOMA-341
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4205
Abstract: MOMA-341, first disclosed herein, is a novel, potent, and selective clinical stage small molecule inhibitor of the Werner RecQ like helicase (WRN) that acts through an allosteric, ATP-competitive binding mechanism and covalent ligation of WRN… read more here.
Keywords: repeat; moma 341; wrn; sensitivity ... See more keywords
Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0174
Abstract: In patients with colorectal cancer, the presence of Fusobacterium nucleatum may suppress immune responses for microsatellite instability (MSI)-high tumors and encourage immune responses for non-MSI-high tumors. F. nucleatum and MSI status interact to affect antitumor… read more here.
Keywords: status; nucleatum; msi status; cancer ... See more keywords
Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6227-7
Abstract: BackgroundMicrosatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive… read more here.
Keywords: status; status using; msi; msi status ... See more keywords
Deciphering mismatch repair protein expression variability in gastric cancer: clinical and prognostic implications
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-14857-8
Abstract: Gastric cancer (GC) exhibits diverse molecular characteristics, among which microsatellite instability (MSI) plays a pivotal role in determining treatment responses, particularly to immune checkpoint inhibitors (ICIs). Mismatch repair (MMR) protein immunohistochemical (IHC) staining is a… read more here.
Keywords: cancer; msi; mismatch repair; msi status ... See more keywords
Relationship of HER2 alteration and MSI status in colorectal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.121
Abstract: 121Background: The impact of HER2 somatic mutations in colorectal carcinoma (CRC) has not been well studied and its relationship with MSI-H is an open question. Methods: From February 2017 to Febru... read more here.
Keywords: msi; alteration msi; her2 alteration; relationship ... See more keywords
Magnetic resonance-based radiomics nomogram for predicting microsatellite instability status in endometrial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-22-255
Abstract: Background Microsatellite instability (MSI) status is an important indicator for screening patients with endometrial cancer (EC) who have potential Lynch syndrome (LS) and may benefit from immunotherapy. This study aimed to develop a magnetic resonance… read more here.
Keywords: radiomics nomogram; msi status; status; model ... See more keywords
The value of magnetic resonance imaging-based tumor shape features for assessing microsatellite instability status in endometrial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-22-77
Abstract: Background Microsatellite instability (MSI) status can be used for the classification and risk stratification of endometrial cancer (EC). This study aimed to investigate whether magnetic resonance imaging (MRI)-based tumor shape features can help assess MSI… read more here.
Keywords: msi status; shape features; status; based tumor ... See more keywords
Prediction of Microsatellite Instability in Colorectal Cancer Using a Machine Learning Model Based on PET/CT Radiomics
Sign Up to like & getrecommendations! Published in 2023 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2022.0548
Abstract: Purpose We investigated the feasibility of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) radiomics with machine learning to predict microsatellite instability (MSI) status in colorectal cancer (CRC) patients. Materials and Methods Altogether, 233… read more here.
Keywords: msi status; rad score; machine learning; microsatellite instability ... See more keywords
Radiomics features based on internal and marginal areas of the tumor for the preoperative prediction of microsatellite instability status in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1020349
Abstract: Objectives To explore whether the preoperative CT radiomics can predict the status of microsatellite instability (MSI) in colorectal cancer (CRC) patients and identify the region with the most stable and high-efficiency radiomics features. Methods This… read more here.
Keywords: microsatellite instability; msi status; status; colorectal cancer ... See more keywords