NAV-003, A Bispecific Antibody Targeting A Unique Mesothelin Epitope and CD3ε With Improved Cytotoxicity Against Humoral Immunosuppressed Tumors.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250309
Abstract: Mesothelin (MSLN) is a cell surface protein over-expressed in a number of cancer types. Several antibody- and cellular-based MSLN targeting agents have been tested in clinical trials where their therapeutic efficacy has been moderate at… read more here.
Keywords: cd3; mesothelin; bispecific antibody; nav 003 ... See more keywords
Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0472-9
Abstract: Pancreatic cancer is a devastating disease ranked as the 4th leading cause of cancer-related deaths in the United States, and its incidence rate is increasing according to the latest statistics. The overall survival rates for… read more here.
Keywords: msln; pancreatic cancer; mesothelin; cancer ... See more keywords
Construction of a 124I-Labeled Specific Antibody for the Noninvasive Detection of Mesothelin-Overexpressing Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00342
Abstract: Mesothelin (MSLN) is a molecular biomarker of many types of solid tumors, such as mesothelioma, pancreatic cancer, and colon cancer. Owing to the significant difference in expression between cancer cells and normal cells, mesothelin has… read more here.
Keywords: mesothelin; anti msln; 124i anti; msln ... See more keywords
Novel single‐chain variant of antibody against mesothelin established by phage library
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14150
Abstract: Mesothelin (MSLN) shows increased expression in various cancer cells. For clinical application of antibodies as a positron emission tomography (PET) imaging reagent, a human shortened antibody is essential both for avoiding redundant immune responses and… read more here.
Keywords: msln; phage; phage library; scfv ... See more keywords
P01.07 Targeting a membrane proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on tumor cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.20
Abstract: Background Mesothelin (MSLN) is recognized as a relevant tumor-associated antigen for cancer immunotherapy, because of its overexpression on various solid tumors, including mesothelioma, pancreatic, lung, gastric and ovarian carcinoma. However, an anti-MSLN monoclonal antibody (mAb),… read more here.
Keywords: none; msln; membrane proximal; targeting membrane ... See more keywords
Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003826
Abstract: Background Mesothelin (MSLN) is a classic tumor-associated antigen that is expressed in lung cancer and many other solid tumors. However, MSLN is also expressed in normal mesothelium which creates a significant risk of serious inflammation… read more here.
Keywords: msln car; tmod; car; msln ... See more keywords
Abstract 1280: Role of soluble mesothelin in peritoneal metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1280
Abstract: The cell-surface glycoprotein mesothelin (MSLN) is overexpressed in pancreatic adenocarcinoma (PDAC) and is positively correlated with tumor aggressiveness. MSLN knock-out (KO) PDAC cells have delayed growth of peritoneal metastases in mice. Complementation with wild-type MSLN… read more here.
Keywords: mesothelin; peritoneal metastasis; growth; msln ... See more keywords
Abstract 5666: NAV-003, a full-length IgG1 bispecific antibody targeting a unique mesothelin epitope and CD3 to improve cytotoxicity against humoral immunosuppressed tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5666
Abstract: Mesothelin (MSLN) is a cell surface protein over-expressed in a number of cancer types. Several antibody- and cellular-based MSLN targeting agents have been tested in clinical trials where their therapeutic efficacy has been moderate at… read more here.
Keywords: cd3; mesothelin; bispecific antibody; nav 003 ... See more keywords
Comparative gene expression analysis in lung cancer
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DOI: 10.1183/13993003.congress-2018.pa2797
Abstract: Introduction: Since the most common lung cancers are lung adenocarcinoma, squamous lung cancer (SLC) and the small cell lung cancer (SCLC), a comparative diferential expression between these types of lung cancer deserves investigation. Material and… read more here.
Keywords: msln; sclc; expression; lung cancer ... See more keywords
A Novel PD-L1-Containing MSLN Targeting Vaccine for Lung Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.925217
Abstract: Therapeutic tumor vaccines have become an important breakthrough in the treatment of various solid tumors including lung cancer. Dendritic cells (DCs)-based tumor vaccines targeting tumor-associated antigens (TAAs) play a key role in immunotherapy and immunoprevention.… read more here.
Keywords: lung cancer; vaccine; msln; tumor ... See more keywords
Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer
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DOI: 10.3892/ol.2020.11290
Abstract: Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein that is highly expressed in several types of malignant tumor, including malignant pleural mesothelioma, ovarian cancer and pancreatic adenocarcinoma. Recently, a comprehensive immunohistochemical study using MN-1… read more here.
Keywords: msln; colorectal cancer; proliferation; msln expression ... See more keywords