Mesothelin Expression in Patients with High-Grade Serous Ovarian Cancer Does Not Predict Clinical Outcome But Correlates with CD11c+ Expression in Tumor
Sign Up to like & getrecommendations! Published in 2020 at "Advances in Therapy"
DOI: 10.1007/s12325-020-01520-w
Abstract: Mesothelin (MSLN) is overexpressed in several tumors including ovarian cancer and is the target of current trials. There is limited and conflicting data on MSLN prognostic impact in ovarian cancer. We performed a retrospective study… read more here.
Keywords: outcome; msln expression; expression; ovarian cancer ... See more keywords
Mesothelin Expression is Correlated with Chemoresistance in Stage IV Colorectal Cancer
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DOI: 10.1245/s10434-021-10507-y
Abstract: Mesothelin (MSLN) is a cell-surface glycoprotein present on mesothelial cells; its expression in several epithelial cancers generally portends an unfavorable prognosis. We investigated MSLN as a surrogate chemopredictive biomarker and examined the impact of MSLN… read more here.
Keywords: stage colorectal; low msln; colorectal cancer; msln expression ... See more keywords
Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer
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DOI: 10.3390/ijms23031016
Abstract: Mesothelin (MSLN) overexpression (OE) is a frequent finding in ovarian carcinomas and increases cell survival and tumor aggressiveness. Since cancer stem cells (CSCs) contribute to pathogenesis, chemoresistance and malignant behavior in ovarian cancer (OC), we… read more here.
Keywords: msln expression; cell; cancer stem; expression ... See more keywords
Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer
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DOI: 10.3892/ol.2020.11290
Abstract: Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein that is highly expressed in several types of malignant tumor, including malignant pleural mesothelioma, ovarian cancer and pancreatic adenocarcinoma. Recently, a comprehensive immunohistochemical study using MN-1… read more here.
Keywords: msln; colorectal cancer; proliferation; msln expression ... See more keywords