Fabrication and characterization of bioactive chitosan microspheres incorporated with mesoporous silica nanoparticles for biomedical applications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Porous Materials"
DOI: 10.1007/s10934-019-00837-4
Abstract: Mesoporous silica nanoparticles (MSNs) were prepared using sol–gel method. Chitosan-MSNs microspheres scaffold loaded with ciprofloxacin also prepared via an ionotropic gelation method. The prepared samples were characterized using FE-SEM, TEM, FTIR and XRD analysis. The… read more here.
Keywords: msns; fabrication characterization; mesoporous silica; silica nanoparticles ... See more keywords
Targeted and controlled drug delivery by multifunctional mesoporous silica nanoparticles with internal fluorescent conjugates and external polydopamine and graphene oxide layers.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.022
Abstract: This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene… read more here.
Keywords: msns; controlled release; delivery; mesoporous silica ... See more keywords
CX-5461-loaded nucleolus-targeting nanoplatform for cancer therapy through induction of pro-death autophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.08.035
Abstract: Various drugs have been designed in the past to act on intracellular targets. For the desired effects to be exerted, these drugs should reach and accumulate in specific subcellular organelles. CX-5461 represents a potent small-molecule… read more here.
Keywords: 5461 loaded; death autophagy; msns; pro death ... See more keywords
High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.05.031
Abstract: Subtypes of nucleus accumbens medium spiny neurons (MSNs) promote dichotomous outcomes in motivated behaviors. However, recent reports indicate enhancing activity of either nucleus accumbens (NAc) core MSN subtype augments reward, suggesting coincident MSN activity may… read more here.
Keywords: high frequency; msns; nucleus accumbens; activation ... See more keywords
Nanocontainer-Enhanced Self-Healing for Corrosion-Resistant Ni Coating on Mg Alloy.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b12036
Abstract: The ability to manipulate the functionalization of Ni coating is of great importance in improving the corrosion resistance of magnesium (Mg) alloy for many industrial applications. In the present work, MCM-41 type mesoporous silica nanocontainers… read more here.
Keywords: alloy; corrosion resistant; msns; corrosion ... See more keywords
Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b09069
Abstract: The use of nanocarriers to deliver poorly soluble drugs to the sites of diseases is an attractive and general method, and mesoporous silica nanoparticles (MSNs) are increasingly being used as carriers. However, both loading a… read more here.
Keywords: cfz; msns; water insoluble; drug ... See more keywords
Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm00822e
Abstract: Photoacoustic (PA) imaging is gaining momentum due to its greater depth of field, low background, and 3D imaging capabilities. However, traditional PA imaging agents (e.g. dyes, quantum dots, etc.) are usually unstable in plasma and… read more here.
Keywords: icg loaded; msns; mesoporous silica; silica nanoparticles ... See more keywords
Striatal network modeling in Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007648
Abstract: Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs display coherent burst firing cell assembly activity patterns, even though isolated MSNs do not burst fire intrinsically. This activity is… read more here.
Keywords: huntington disease; msns; activity; network ... See more keywords
Folic acid–conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25470
Abstract: Naturally derived prodrugs have a wide range of pharmacological activities, including anticancer, antioxidant, and antiviral effects. However, significant barriers inhibit their use in medicine, e.g. their hydrophobicity. In this comprehensive study, we investigated simple and… read more here.
Keywords: folic acid; msns; mesoporous silica; natural prodrugs ... See more keywords
Practical Manipulation for the Preparation of Mesoporous Silica Nanoparticles for Drug Delivery Vehicles.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220901105102
Abstract: BACKGROUND Optimization of MSNs is the most important process for efficient and safe drug delivery systems. OBJECTIVE In this study, the physicochemical properties of MSNs were evaluated using various compositions of individual reagents. METHODS MSNs… read more here.
Keywords: msns; surface area; drug delivery;
Co-delivery of cisplatin and curcumin using mesoporous silica nanoparticles to improve their anticancer effects.
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738511666230327123627
Abstract: AIMS This study aimed to prepare and evaluate the physicochemical and anticancer properties of cisplatin and curcumin-loaded mesoporous silica nanoparticles (Cis-Cur-MSNs). BACKGROUND In recent years, combination treatment has attained better outcomes than monotherapy in oncology.… read more here.
Keywords: msns; cisplatin curcumin; mesoporous silica; cur msns ... See more keywords