Lin28a protects against diabetic cardiomyopathy through Mst1 inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29321
Abstract: Lin28a has been found to enhance glucose uptake and insulin sensitivity. Lin28a alleviates cardiac dysfunction under various pathological conditions. However, the effects and underlying mechanisms of Lin28a on diabetic cardiomyopathy (DCM) are not well‐understood. The… read more here.
Keywords: mst1; mst1 inhibition; high glucose; lin28a ... See more keywords
PCMT1 Ameliorates Neuronal Apoptosis by Inhibiting the Activation of MST1 after Subarachnoid Hemorrhage in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0540-8
Abstract: Mammalian sterile 20-like kinase 1 (MST1) is found to promote neuronal apoptosis. Protein-l-isoaspartate (d-aspartate) O-methyltransferase (PCMT1), an anti-apoptosis factor, was recently identified as an MST1-interacting protein. This study aims to explore the potential role of… read more here.
Keywords: apoptosis; mst1; neuronal apoptosis; subarachnoid hemorrhage ... See more keywords
XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174801
Abstract: Up to now, there are few therapeutic approaches available to protect heart from ischemia/reperfusion (I/R) injury. The present work was designed to examine the protection of XMU-MP-1, an inhibitor of mammalian sterile 20-like kinase 1… read more here.
Keywords: injury; mst1; mice; heart ischemia ... See more keywords
Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101120
Abstract: Obesity-related non-alcoholic fatty liver disease (NAFLD) is connected with mitochondrial stress and hepatocyte apoptosis. Parkin-related mitophagy sustains mitochondrial homeostasis and hepatocyte viability. However, the contribution and regulatory mechanisms of Parkin-related mitophagy in NAFLD are incompletely… read more here.
Keywords: fatty liver; related mitophagy; mst1; parkin related ... See more keywords
Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Research"
DOI: 10.1016/j.scr.2017.02.011
Abstract: Adult fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSC) for use in various applications. However, there are challenges in iPSC generation including low reprogramming efficiency, yield, cell survival and viability. Since the Hippo… read more here.
Keywords: mst1; proliferation survival; efficiency; cell ... See more keywords
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c05889
Abstract: To date, few effective treatments have been licensed for nonalcoholic fatty liver disease (NAFLD), which a kind of chronic liver disease. Mammalian sterile 20-like kinase 1 (MST1) is reported to be involved in the development… read more here.
Keywords: nanoparticle; mst1; hepatic steatosis; redox unlockable ... See more keywords
Dendritic cell MST1 inhibits Th17 differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14275
Abstract: Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and antifungal inflammation and… read more here.
Keywords: dcs; mst1; th17 differentiation; differentiation ... See more keywords
Mammalian Sterile 20-Like Kinase 1 Suppresses Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Circulation research"
DOI: 10.1161/circresaha.122.321322
Abstract: BACKGROUND Atherosclerosis occurs mainly at arterial branching points exposed to disturbed blood flow. How MST1 (mammalian sterile 20-like kinase 1), the primary kinase in the mechanosensitive Hippo pathway modulates disturbed flow induced endothelial cells (ECs)… read more here.
Keywords: mst1; sterile like; cx43; kinase ... See more keywords
Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00267-6
Abstract: Background Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte apoptosis and maternal diabetes-induced… read more here.
Keywords: yap1; heart; apoptosis; survivin ... See more keywords
Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac143
Abstract: Abstract Recent conditional knockout of core components of the Hippo signaling pathway in the adrenal gland of mice has demonstrated that this pathway must be tightly regulated to ensure proper development and maintenance of the… read more here.
Keywords: adrenal cortex; mouse adrenal; mst1; mst2 ... See more keywords
Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s193787
Abstract: Background and objective Mst1-Hippo pathway and mitochondrial fragmentation participate in the progression of several types of cancers. However, their roles in breast cancer requires investigation. The aim of our study is to determine whether Mst1… read more here.
Keywords: fragmentation; mitochondrial fragmentation; breast cancer; mst1 ... See more keywords