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   Articles with "mst4" as a keyword



MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer

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recommendations! Published in 2022 at "IUBMB Life"

DOI: 10.1002/iub.2682

Abstract: Mammalian ste20‐like kinase 4 (MST4) and autophagy have been implicated in ailments such as inflammatory and cancers. read more here.

Keywords: therapeutic target; mst4 novel; novel therapeutic; autophagy radiosensitivity ... See more keywords

Abstract 4143634: Macrophage MST4 Exacerbates Cardiac Microvascular Ischemia/reperfusion Injury by Phosphorylating ACLY

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recommendations! Published in 2024 at "Circulation"

DOI: 10.1161/circ.150.suppl_1.4143634

Abstract: Background: Cardiac microvascular dysfunction is a contributing factor to cardiac ischemia/reperfusion (I/R) injury. The impact of mammalian Ste20-like kinase 4 (MST4) on cardiac microvascular I/R injury remains unknown. Aims: To decipher the role of MST4… read more here.

Keywords: microvascular injury; cardiac microvascular; macrophage; cell ... See more keywords

MicroRNA-486-5p inhibits ovarian granulosa cell proliferation and participates in the development of PCOS via targeting MST4.

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recommendations! Published in 2019 at "European Review for Medical and Pharmacological Sciences"

DOI: 10.26355/eurrev_201909_18823

Abstract: Objective To explore whether microRNA-486-5p affected the proliferation of ovarian granulosa cells by targeting MST4 (silk/threonine protein kinase 4), thereby promoting the development of polycystic ovary syndrome (PCOS). Materials and methods The level of microRNA-486-5p… read more here.

Keywords: cycle; cell proliferation; mst4; cell ... See more keywords

Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25042446

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced subtype, metabolic dysfunction-associated steatohepatitis (MASH), have emerged as the most common chronic liver disease worldwide, yet there is no targeted pharmacotherapy presently available. This study aimed… read more here.

Keywords: mice; masld; type; diet ... See more keywords

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis

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recommendations! Published in 2021 at "Journal of Cancer"

DOI: 10.7150/jca.60008

Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has a poor prognosis due to the high incidence of invasion and metastasis-related progression. However, the underlying mechanism remains elusive, and valuable… read more here.

Keywords: mst4; hcc; invasion; snail1 ... See more keywords