CRISPR/Cas9‐mediated sheep MSTN gene knockout and promote sSMSCs differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27474
Abstract: Myostatin (MSTN) is an important gene involved in the regulation of embryonic muscle cells and adult muscle development; it has a good application prospect in transgenic animal production by improving the yield of muscle. The… read more here.
Keywords: mstn gene; mstn; crispr cas9; gene knockout ... See more keywords
The association between the polymorphism in the myostatin gene and growth traits in Kamieniec and Pomeranian sheep breeds
Sign Up to like & getrecommendations! Published in 2019 at "Small Ruminant Research"
DOI: 10.1016/j.smallrumres.2019.06.007
Abstract: Abstract The aim of the study was to identify polymorphisms in c.*1232 position and in the first intron of ovine myostatin gene (MSTN) in Kamieniec and Pomeranian sheep breeds and investigate the association between detected… read more here.
Keywords: kamieniec pomeranian; mstn mstn; growth traits; sheep ... See more keywords
Comparison of gene editing efficiencies of CRISPR/Cas9 and TALEN for generation of MSTN knock-out cashmere goats.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.03.029
Abstract: The genome editors CRISPR/Cas9 (clustered regularly interspaced short palindromicrepeats/Cas9 nuclease-null) and TALENs (transcription activator-like effector nuclease) are popularly used for targeted modification of the mammalian genome. To date, few comparative studies have been carried out… read more here.
Keywords: mstn; crispr cas9; cas9 talen; gene ... See more keywords
Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46362
Abstract: Myostatin (Mstn) is a skeletal muscle growth inhibitor involved in metabolic disorders and heart fibrosis. In this study we sought to verify whether Mstn is also operative in atherosclerosis of abdominal aorta. In human specimens,… read more here.
Keywords: mstn; muscle; smooth muscle; atherosclerosis progression ... See more keywords
Generation of cloned adult muscular pigs with myostatin gene mutation by genetic engineering
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra28579a
Abstract: Skeletal muscle is the most economically valuable tissue in meat-producing animals and enhancing muscle growth in these species may enhance the efficiency of meat production. Skeletal muscle mass is negatively regulated by myostatin (MSTN), and… read more here.
Keywords: mstn; generation cloned; muscular pigs; adult muscular ... See more keywords
‘Double-muscling’ and pelvic tilt phenomena in rabbits with the cystine-knot motif deficiency of myostatin on exon 3
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190207
Abstract: Gene mutations at different gene sites will produce totally different phenotypes or biological functions in gene-edited animals. An allelic series of mutations in the myostatin (MSTN) gene can cause the ‘double-muscling’ phenotype. Although there have… read more here.
Keywords: knot motif; cystine knot; mstn rabbits; pelvic tilt ... See more keywords
Effects of myostatin gene knockout on porcine extraocular muscles.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2077741
Abstract: Myostatin (MSTN), a negative regulator of skeletal muscle mass, is not well known in extraocular muscles (EOMs). EOMs are specialized skeletal muscles. Hence, in this study, the effect of MSTN on the superior rectus (SR)… read more here.
Keywords: mstn; knockout; extraocular muscles; pigs mstn ... See more keywords
Comprehensive analysis of circRNAs and lncRNAs involvement in the development of skeletal muscle in myostatin-deficient rabbits.
Sign Up to like & getrecommendations! Published in 2025 at "Animal biotechnology"
DOI: 10.1080/10495398.2025.2465624
Abstract: Abstract Myostatin (MSTN) protein, lncRNAs, and circRNAs regulate skeletal muscle growth and development. This work aims to compare the expression patterns of circRNAs and lncRNAs in the gluteus maximus tissue of wild-type (WT) and MSTN… read more here.
Keywords: skeletal muscle; muscle; circrnas lncrnas; mstn ... See more keywords
PSIII-8 CRISPR editing of IGF2 and MSTN to enhance productivity
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Animal Science"
DOI: 10.1093/jas/skae234.577
Abstract: The ability to modify the genomes of livestock species has previously been limited by low efficiency and the high cost associated with reagents and the generation of edited live animals (e.g., via somatic cell nuclear… read more here.
Keywords: psiii crispr; cell; loss function; mstn ... See more keywords
Significance of serum Myostatin in hemodialysis patients
Sign Up to like & getrecommendations! Published in 2019 at "BMC Nephrology"
DOI: 10.1186/s12882-019-1647-9
Abstract: BackgroundMalnutrition and muscle wasting are common in haemodialysis (HD) patients. Their pathogenesis is complex and involves many molecules including Myostatin (Mstn), which acts as a negative regulator of skeletal muscle. The characterisation of Mstn as… read more here.
Keywords: myostatin; malnutrition; mstn; muscle ... See more keywords
Myostatin inhibits glucose uptake via suppression of insulin‐dependent and ‐independent signaling pathways in myoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13837
Abstract: The glucose transporter 4 (Glut4) mediates insulin‐dependent glucose uptake. Glut4 expression levels are correlated with whole‐body glucose homeostasis. Insulin signaling is known to recruit Glut4 to the cell surface. Expression of Glut4 is subject to… read more here.
Keywords: insulin; insulin dependent; mstn; glucose uptake ... See more keywords