Phosphoinositide‐3 kinase gamma regulates caspase‐1 activation and leukocyte recruitment in acute murine gout
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.ma1118-470rr
Abstract: This study investigates the participation of PI3Kγ in the development of joint inflammation and dysfunction in an experimental model of acute gout in mice. Acute gout was induced by injection of monosodium urate (MSU) crystals… read more here.
Keywords: caspase activation; gout; msu; pi3k ... See more keywords
Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib
Sign Up to like & getrecommendations! Published in 2020 at "Modern Rheumatology"
DOI: 10.1080/14397595.2020.1740410
Abstract: Abstract Objectives Gout is an inflammatory arthropathy caused by the deposition of monosodium urate (MSU). The synthesis and release of IL-1β is crucial for MSU-induced synovial inflammation. The aim of the present study was to… read more here.
Keywords: uric acid; inflammasome activation; msu; acid mediated ... See more keywords
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac367
Abstract: OBJECTIVES To evaluate whether ultrasound (US) findings indicating monosodium urate (MSU) deposits and US-detected inflammation [i.e. power Doppler (PD) signal] predict gout flares over 12 months. METHODS Gout patients on urate-lowering therapy for at least the… read more here.
Keywords: rheumatology; msu deposits; gout; msu ... See more keywords
Dual-Energy Computed Tomography for Detection and Characterization of Monosodium Urate, Calcium Pyrophosphate, and Hydroxyapatite
Sign Up to like & getrecommendations! Published in 2021 at "Investigative Radiology"
DOI: 10.1097/rli.0000000000000756
Abstract: Supplemental digital content is available in the text. Objectives The aim of this study was to determine the diagnostic performance of dual-energy computed tomography (DECT) to detect and distinguish crystal deposits in a phantom. The… read more here.
Keywords: crystal; dect; msu; dual energy ... See more keywords
Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-222764
Abstract: Objective Increasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since the relationship between cartilage matrix protein and gout flares remains unclear, we investigated its role… read more here.
Keywords: msu crystallisation; type collagen; cartilage; gouty arthritis ... See more keywords
P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/3317307
Abstract: Activation of the nod-like receptor protein 3 (NLRP3) inflammasome by monosodium urate (MSU) crystals has been identified as the molecular basis for the acute inflammatory response in gouty arthritis. However, MSU crystals alone are not… read more here.
Keywords: effect atp; msu crystals; synergistic effect; msu ... See more keywords
Abstract 2: Intracranial Hemorrhage Managed By A Mobile Stroke Unit
Sign Up to like & getrecommendations! Published in 2024 at "Stroke"
DOI: 10.1161/str.55.suppl_1.2
Abstract: Background: Mobile stroke units (MSUs) improve outcomes in thrombolytic-eligible ischemic stroke patients. Outcomes of MSU management in patients with intracranial hemorrhage (ICH) have not been reported. Methods: We conducted a retrospective review of ICH patients… read more here.
Keywords: stroke; intracranial hemorrhage; mobile stroke; management ... See more keywords
Economic evaluation of the Melbourne Mobile Stroke Unit
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Stroke"
DOI: 10.1177/1747493020929944
Abstract: Background The Melbourne Mobile Stroke Unit (MSU) is the first Australian service to provide prehospital acute stroke treatment, including thrombolysis and facilitated triage for endovascular thrombectomy. Aims To estimate the cost-effectiveness of the MSU during… read more here.
Keywords: msu; mobile stroke; stroke unit; melbourne mobile ... See more keywords
Analysis of the use of a mobile simulation unit using the principles of a managed educational network.
Sign Up to like & getrecommendations! Published in 2021 at "Rural and remote health"
DOI: 10.22605/rrh5670
Abstract: INTRODUCTION One of the challenges of delivering safe, reliable, quality health care is ensuring the workforce have access to the right training at the right time wherever they are practising. Like other high reliability fields,… read more here.
Keywords: managed educational; mobile simulation; msu; education ... See more keywords
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db18-0912
Abstract: We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found… read more here.
Keywords: diabetic retinopathy; msu; retinal inflammation; monosodium urate ... See more keywords
The pathogenic mechanism of monosodium urate crystal-induced kidney injury in a rat model
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1416996
Abstract: Objective (MSU) crystals usually in the kidney tubules especially collecting ducts in the medulla. Previous animal models have not fully reproduced the impact of MSU on kidneys under non-hyperuricemic conditions. Methods In the group treated… read more here.
Keywords: rat model; injection; group; msu ... See more keywords