FRI0710 Monosodium urate crystal deposition associated with the change of radiographic grade at the sacroiliac joint in axial spa: a dual-energy ct study
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.1417
Abstract: Background Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by the insidiously progressive nature of sacroiliitis and spondylitis. Dual-energy computed tomography (DECT) has recently been… read more here.
Keywords: msu crystal; crystal deposits; sacroiliac joint;
SAT0009 Tyrosine kinase pathways in monosodium-urate crystal-induced inflammatory responses
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5172
Abstract: Background Deposition of monosodium urate (MSU) crystals in the joints or other tissues is a hallmark in the pathogenesis of gout. The urate crystal-induced inflammation is known to be mediated mainly by neutrophils besides monocytes… read more here.
Keywords: crystal induced; src family; crystal; family kinases ... See more keywords
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals
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DOI: 10.1155/2022/5064494
Abstract: Excessive generation of reactive oxygen species (ROS) has great impacts on MSU crystal-induced inflammation. Drp1-dependent mitochondrial fission is closely associated with mitochondrial ROS levels. However, whether Drp1 signaling contributes to MSU crystal-induced inflammation remains unclear.… read more here.
Keywords: crystal; msu crystal; crystal induced; msu crystals ... See more keywords
In situ Synthesized Monosodium Urate Crystal Enhances Endometrium Decidualization via Sterile Inflammation During Pregnancy
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DOI: 10.3389/fcell.2021.702590
Abstract: High level of uric acid (UA) is the major origin of gout, and is highly associated with various pregnant complications, such as preeclampsia and gestational diabetes. However, UA’s level and role in the very early… read more here.
Keywords: pregnancy; level; early stage; decidualization ... See more keywords
POP1 inhibits MSU-induced inflammasome activation and ameliorates gout
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.912069
Abstract: Canonical inflammasomes are innate immune protein scaffolds that enable the activation of inflammatory caspase-1, and subsequently the processing and release of interleukin (IL)-1β, IL-18, and danger signals, as well as the induction of pyroptotic cell… read more here.
Keywords: msu crystal; inflammasome assembly; inflammasome activation; pop1 ... See more keywords