Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01299-6
Abstract: The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1β and is considered a main pathogenic mechanism for uric acid-induced inflammation. Whether toll-like receptor 9 (TLR9) is responsible… read more here.
Keywords: inflammasome activation; dna; msu crystals; nlrp3 inflammasome ... See more keywords
Urate in fingernail represents the deposition of urate burden in gout patients
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72505-6
Abstract: Urate in the fingernails of gout patients and healthy volunteers was successfully detected by high-performance liquid chromatography (HPLC) with ultraviolet (UV) in our previous research. This study aimed to further investigate whether nail urate could… read more here.
Keywords: msu crystals; burden; crystals deposits; nail urate ... See more keywords
CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13371
Abstract: Gout is an inflammatory disease triggered by deposition of monosodium urate (MSU) crystals in the joints, resulting in high neutrophil influx and pain. Here, we studied the role of the inhibitory receptor CD300a in the… read more here.
Keywords: resolution; cd300a; cd300a mice; msu crystals ... See more keywords
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5064494
Abstract: Excessive generation of reactive oxygen species (ROS) has great impacts on MSU crystal-induced inflammation. Drp1-dependent mitochondrial fission is closely associated with mitochondrial ROS levels. However, whether Drp1 signaling contributes to MSU crystal-induced inflammation remains unclear.… read more here.
Keywords: crystal; msu crystal; crystal induced; msu crystals ... See more keywords
P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/3317307
Abstract: Activation of the nod-like receptor protein 3 (NLRP3) inflammasome by monosodium urate (MSU) crystals has been identified as the molecular basis for the acute inflammatory response in gouty arthritis. However, MSU crystals alone are not… read more here.
Keywords: effect atp; msu crystals; synergistic effect; msu ... See more keywords
Novel Leflunomide Analog, UTLOH-4e, ameliorates gouty arthritis induced by monosodium urate via NF.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230420101219
Abstract: BACKGROUND Gouty arthritis (GA) is a common form of inflammatory arthritis caused by intra-articular deposition of monosodium urate (MSU) crystals. However, it can not be cured at present. OBJECTIVE The goal of this work was… read more here.
Keywords: monosodium urate; novel leflunomide; arthritis; msu crystals ... See more keywords
Urate Crystals; Beyond Joints
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.649505
Abstract: Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United… read more here.
Keywords: extra articular; deposition; urate crystals; msu crystals ... See more keywords
C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00010
Abstract: Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β.… read more here.
Keywords: monosodium urate; production; msu; msu crystals ... See more keywords
A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1β secretion through inhibition of NF-κB signaling and NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15295
Abstract: Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues. MSU crystals activate the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome to… read more here.
Keywords: r14 peptide; msu crystals; wild rice; crystals induced ... See more keywords