FUS oncofusion protein condensates recruit mSWI/SNF chromatin remodeler via heterotypic interactions between prion‐like domains
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4127
Abstract: Fusion transcription factors generated by genomic translocations are common drivers of several types of cancers including sarcomas and leukemias. Oncofusions of the FET (FUS, EWSR1, and TAF15) family proteins result from the fusion of the… read more here.
Keywords: protein; chromatin; prion like; pld ... See more keywords
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3853
Abstract: Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood.… read more here.
Keywords: smarcd2 containing; mswi snf; snf complex; granulopoiesis ... See more keywords
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
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DOI: 10.1126/science.abf8705
Abstract: Chromatin landscape dictates remodeling Large, multicomponent molecular machines known as mammalian SWI/SNF (mSWI/SNF) chromatin-remodeling complexes play critical roles in governing the architecture of our genomes. These entities bind to chromatin (DNA assembled on proteins) inside… read more here.
Keywords: landscape signals; chromatin; mswi snf; chromatin landscape ... See more keywords
Abstract 1794: Targeting mammalian SWI/SNF chromatin remodeling complexes to improve T cell-based cancer immunotherapies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1794
Abstract: T cell activation and exhaustion are associated with highly coordinated changes in gene expression and chromatin accessibility. While the contribution of key, state-specific transcription factors to these processes has been extensively explored, the role for… read more here.
Keywords: cell; exhaustion; chromatin; snf ... See more keywords
Abstract 3485: Intrinsically disordered regions of the ARID1A/B tumor suppressors encode an interaction network within biomolecular condensates that directs mSWI/SNF chromatin remodeler complex activity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3485
Abstract: The mammalian SWI/SNF (mSWI/SNF or BAF) ATP-dependent chromatin remodeling complexes collectively represent one of the most frequently mutated cellular entities in cancer, second only to TP53. Mutations across the 29 human genes that encode mSWI/SNF… read more here.
Keywords: network; intrinsically disordered; disordered regions; baf ... See more keywords
SWI/SNF Dysregulation through a Prion-like Domain Causes AML
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DOI: 10.1182/blood-2019-129280
Abstract: Meningioma-1 (MN1) was first described in a sporadic t(4;22) translocation in meningioma. Rare MN1 fusions to the ETS factors ETV6 (t(12;22)) and FLI1 (cryptic) also occur in AML. t(12;22) translocations have been described in two… read more here.
Keywords: protein; mn1; prion like; polyq stretch ... See more keywords
Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain
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DOI: 10.3389/fcell.2021.619538
Abstract: Oligodendrocytes are responsible for axon myelination in the brain and spinal cord. Generation of oligodendrocytes entails highly regulated multistage neurodevelopmental events, including proliferation, differentiation and maturation. The chromatin remodeling BAF (mSWI/SNF) complex is a notable… read more here.
Keywords: baf; baf mswi; scaffolding subunits; proliferation ... See more keywords