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   Articles with "mt1" as a keyword



Tethered Exosomes Containing the Matrix Metalloproteinase MT1‐MMP Contribute to Extracellular Matrix Degradation

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recommendations! Published in 2025 at "Journal of Extracellular Vesicles"

DOI: 10.1002/jev2.70122

Abstract: ABSTRACT For cancer cells to escape from the primary tumour and metastasize, they must degrade and navigate through the extracellular matrix (ECM). The transmembrane protease MT1‐matrix metalloprotease (MMP) plays a key role in localized matrix… read more here.

Keywords: mt1; extracellular matrix; mt1 mmp; matrix degradation ... See more keywords
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PLD and PA Take MT1-MMP for a Metastatic Ride.

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recommendations! Published in 2017 at "Developmental cell"

DOI: 10.1016/j.devcel.2017.10.012

Abstract: Polarized targeting and deposition of MT1-MMP is pivotal for metastasis. In this issue of Developmental Cell, Wang et al. (2017) reveal that a signaling molecule generated by phospholipase D2 drives deposition of MT1-MMP at the site of… read more here.

Keywords: mt1; mt1 mmp; pld take; take mt1 ... See more keywords

Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function.

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recommendations! Published in 2017 at "Reproductive biology"

DOI: 10.1016/j.repbio.2017.10.005

Abstract: Melatonin receptor 1 (MT1) performs a critical role in the regulation of the animal reproductive system, particularly in follicular growth, and has a considerable effect on reproductive performance. However, the role that MT1 plays in… read more here.

Keywords: follicle stimulating; cell; mt1; function ... See more keywords

Adrenal MT1 melatonin receptor expression is linked with seasonal variation in social behavior in male Siberian hamsters

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recommendations! Published in 2022 at "Hormones and Behavior"

DOI: 10.1016/j.yhbeh.2021.105099

Abstract: Many animals exhibit pronounced changes in physiology and behavior on a seasonal basis, and these adaptations have evolved to promote survival and reproductive success. While the neuroendocrine pathways mediating seasonal reproduction are well-studied, far less… read more here.

Keywords: siberian hamsters; adrenal mt1; melatonin; social behavior ... See more keywords

71949 - Melatonin MT1 Receptor Expression in Luminal Invasive Ductal Breast Carcinoma in Postmenopausal Women

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recommendations! Published in 2024 at "British Journal of Surgery"

DOI: 10.1093/bjs/znae175.029

Abstract: Laboratory and animal studies indicate that melatonin exerts a negative impact on breast cancer progression and metastasis. These actions are both receptor dependent and independent. Of the two transmembrane melatonin receptors identified in humans, breast… read more here.

Keywords: breast cancer; breast; mt1; expression ... See more keywords

Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease

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recommendations! Published in 2024 at "Journal of Pineal Research"

DOI: 10.1111/jpi.12948

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α‐synuclein (α‐syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved… read more here.

Keywords: mt1; sirt1 nrf2; ferroptosis; gpx4 pathway ... See more keywords

Endogenous and Exogenous Melatonin Exposure Attenuates Hepatic MT1 Melatonin Receptor Protein Expression in Rat

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recommendations! Published in 2019 at "Antioxidants"

DOI: 10.3390/antiox8090408

Abstract: Melatonin receptors are highly relevant for the hepatoprotective effects of the pineal hormone melatonin after experimental hemorrhagic shock in rats. In this study, we sought to determine the spatial expression pattern and a putative regulation… read more here.

Keywords: protein; mt1; exposure; hemorrhagic shock ... See more keywords

Melatonin Promotes Antler Growth by Accelerating MT1-Mediated Mesenchymal Cell Differentiation and Inhibiting VEGF-Induced Degeneration of Chondrocytes

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23020759

Abstract: The sika deer is one type of seasonal breeding animal, and the growth of its antler is affected by light signals. Melatonin (MLT) is a neuroendocrine hormone synthesized by the pineal gland and plays an… read more here.

Keywords: antler growth; mesenchymal cell; vegf; growth ... See more keywords

Expression and prognostic significance of melatonin receptor MT1 in patients with gastric adenocarcinoma.

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recommendations! Published in 2019 at "Neoplasma"

DOI: 10.4149/neo_2019_190220n141

Abstract: Melatonin receptor type 1 (MTNR1A or MT1) is known to play an important role in cancer progression; however, its prognostic value for resected gastric adenocarcinoma (RGA) is unknown. In this study, we examined the potential… read more here.

Keywords: expression; gastric adenocarcinoma; melatonin receptor; prognostic significance ... See more keywords