Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep
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DOI: 10.1111/jpi.12544
Abstract: The pharmacological potential of targeting selectively melatonin MT1 or MT2 receptors has not yet been exploited in medicine. Research using selective MT1/MT2 receptor ligands and MT1/MT2 receptor knockout mice has indicated that the activation of… read more here.
Keywords: melatonin mt1; mt1 mt2; mt2; mt2 receptors ... See more keywords
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors
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DOI: 10.1111/jpi.12825
Abstract: Melatonin, through its G protein‐coupled receptor (GPCR) (MTNR1B gene) MT2, is implicated in analgesia, but the relationship between MT2 receptors and the opioid system remains elusive. In a model of rodent neuropathic pain (spared nerve… read more here.
Keywords: melatonin mt2; mt2 receptors; mt2; mor ... See more keywords