Articles with "mta" as a keyword



Identification and validation of l‐asparaginase as a potential metabolic target against Mycobacterium tuberculosis

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Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27169

Abstract: Multidrug‐resistant Mycobacterium tuberculosis (Mtb) has emerged as a major health challenge, necessitating the search for new molecular targets. A secretory amidohydrolase, l‐asparaginase of Mtb (MtA), originally implicated in nitrogen assimilation and neutralization of acidic microenvironment… read more here.

Keywords: mycobacterium tuberculosis; mta; target; active site ... See more keywords
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Effectiveness of the static-guided endodontic technique for accessing the root canal through MTA and its effect on fracture strength

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Published in 2020 at "Clinical Oral Investigations"

DOI: 10.1007/s00784-020-03507-x

Abstract: (1) To evaluate the effectiveness of the static-guided (SG) endodontics technique for accessing the root canal through the mineral trioxide aggregate (MTA) and (2) to evaluate the effect of this technique on the fracture strength… read more here.

Keywords: technique; mta; group; fracture strength ... See more keywords

Evaluation of the properties of Mineral Trioxide Aggregate mixed with Zinc Oxide exposed to different environmental conditions

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Published in 2020 at "Bioactive Materials"

DOI: 10.1016/j.bioactmat.2020.04.001

Abstract: Addition of zinc oxide (ZnO) to Mineral Trioxide Aggregate (MTA) has been shown to rectify tooth discoloration caused by Angelus MTA. This study evaluated the microhardness, compressive strength, calcium ion release and crystalline structures of… read more here.

Keywords: proroot mta; mta; compressive strength; environmental conditions ... See more keywords
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Temperature-dependent secondary conversion of primary products from methanol aromatization in a two-stage fluidized bed

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Published in 2020 at "Fuel"

DOI: 10.1016/j.fuel.2020.117204

Abstract: Abstract Methanol to aromatics (MTA) following dual cycles concept unavoidably produced considerable amounts of olefinic intermediates and paraffinic by-products. Their formation and further conversion were vital to improving aromatics production. In this study, a two-stage fluid… read more here.

Keywords: temperature; secondary conversion; mta; conversion ... See more keywords

Effects of smear layer removal agents on the physical properties and microstructure of mineral trioxide aggregate cement.

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Published in 2017 at "Journal of dentistry"

DOI: 10.1016/j.jdent.2017.08.018

Abstract: OBJECTIVE To compare the effect of QMix (Dentsply Sirona), 7% maleic acid (MA), and 17% ethylenediaminetetraacetic acid (EDTA) on the microhardness, flexural strength and microstructure of mineral trioxide aggregate (MTA; ProRoot MTA, Dentsply Sirona). METHODS… read more here.

Keywords: flexural strength; physical properties; distilled water; mta ... See more keywords

Effects of mineral trioxide aggregate and bioceramics on macrophage differentiation and polarization in vitro.

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Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"

DOI: 10.1016/j.jfma.2019.07.010

Abstract: BACKGROUND/PURPOSE Mineral trioxide aggregate (Pro-Root MTA, PR-MTA) and bioceramics (iRoot® SP Injectable Root Canal Sealer, iR-BC) are used for making apical plugs used in apexification, repairing root perforations during root canal therapy, and treating internal… read more here.

Keywords: raw 264; mineral trioxide; mta; mta induced ... See more keywords

Anti‐osteoclastogenesis of Mineral Trioxide Aggregate through Inhibition of the Autophagic Pathway

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Published in 2017 at "Journal of Endodontics"

DOI: 10.1016/j.joen.2016.12.013

Abstract: Introduction: Mineral trioxide aggregate (MTA) regulates bone remodeling, particularly osteoclast differentiation. However, intracellular mechanisms underlying the anti‐osteoclastogenesis of MTA remain unclear. This study aimed to evaluate the potential alterations of autophagic pathway during anti‐osteoclastogenic effects… read more here.

Keywords: trioxide aggregate; autophagic pathway; mta; mta extracts ... See more keywords

Enhancing Effect of Elastinlike Polypeptide‐based Matrix on the Physical Properties of Mineral Trioxide Aggregate

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Published in 2018 at "Journal of Endodontics"

DOI: 10.1016/j.joen.2018.07.017

Abstract: Introduction: Elastinlike polypeptide (ELP) is 1 of the genetically engineered, protein‐based polypeptides, which offers outstanding advantages such as superior biocompatibility, long‐term stability, elasticity, and cost‐effectiveness. This study aimed to investigate the effect of an ELP‐based… read more here.

Keywords: mta; physical properties; matrix physical; based matrix ... See more keywords

Accuracy of the short screening instrument for psychological problems (SSIPPE) in enuresis in the Identification of attention-deficit/ hyperactivity symptoms in the enuretic population.

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Published in 2022 at "Journal of pediatric urology"

DOI: 10.1016/j.jpurol.2022.02.003

Abstract: INTRODUCTION Enuresis prevalence is approximately 5-15% in children aged 6-7 years. The presence of attention deficit hyperactivity disorder (ADHD) in enuretic children is associated with 3 times greater risk of persistent enuresis. The Multimodal Treatment… read more here.

Keywords: enuresis; mta snap; adhd symptoms; enuretic population ... See more keywords

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.

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Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00133

Abstract: It has been shown that PRMT5 inhibition by small molecules can selectively kill cancer cells with homozygous deletion of the MTAP gene if the inhibitors can leverage the consequence of MTAP deletion, namely, accumulation of… read more here.

Keywords: brain; discovery tng908; mtap deleted; mta ... See more keywords

From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy

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Published in 2025 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.4c03101

Abstract: Inhibition of the methyltransferase enzyme PRMT5 by MTA accumulation is a vulnerability of MTAP-deleted cancers. Herein, we report the discovery and optimization of a quinolin-2-amine DEL hit that cooperatively binds PRMT5:MEP50 and MTA to generate… read more here.

Keywords: library screening; mta; dna encoded; prmt5 ... See more keywords