Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers.
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DOI: 10.1021/acs.jmedchem.1c01900
Abstract: The PRMT5•MTA complex has recently emerged as a new synthetically lethal drug target for the treatment of MTAP-deleted cancers. Here, we report the discovery of development candidate MRTX1719. MRTX1719 is a potent and selective binder… read more here.
Keywords: mrtx1719; prmt5 mta; mta complex; mtap deleted ... See more keywords