The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1661
Abstract: Metastasis associated 1 protein (MTA1) is one of the prime facilitators of metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the underlying regulatory mechanism of MTA1 expression in HCC is not clear.… read more here.
Keywords: protein; expression; trim25; mta1 ... See more keywords
Relationship between MTA1 and spread through air space and their joint influence on prognosis of patients with stage I-III lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.07.040
Abstract: OBJECTIVE To characterize the relationship between metastasis-associated protein 1 (MTA1) and spread through air spaces (STAS), and to investigate the joint prognostic value of MTA1 and STAS in resected lung adenocarcinomas. METHODS We retrospectively reviewed… read more here.
Keywords: expression mta1; mta1 stas; expression; mta1 ... See more keywords
Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.19
Abstract: Chromatin remodeling factor metastatic tumor protein 1 (MTA1), one of the most upregulated oncogene in human cancer, has an important role in gene expression, cell survival and promoting hypoxic response. Successful cancer progression is dependent… read more here.
Keywords: sgk1; sgk1 transcription; translocation; repression sgk1 ... See more keywords
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44225
Abstract: Despite a recognized role of DNA methyltransferase 3a (DNMT3a) in human cancer, the nature of its upstream regulator(s) and relationship with the master chromatin remodeling factor MTA1, continues to be poorly understood. Here, we found… read more here.
Keywords: dnmt3a; breast cancer; cancer; mta1 ... See more keywords
Metastasis-Associated Protein 1 Is Involved in Angiogenesis after Transarterial Chemoembolization Treatment
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/6757898
Abstract: Background Transarterial chemoembolization (TACE), a well-established treatment for unresectable hepatocellular carcinoma (HCC), blocks the arterial blood supply to the tumor, which can be short-lived as development of collateral neovessels, leading to the failure of treatment.… read more here.
Keywords: associated protein; angiogenesis; treatment; transarterial chemoembolization ... See more keywords
Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-21-0242
Abstract: Developing novel interceptive strategies for prostate cancer chemoprevention is a paramount goal in clinical oncology. We offer preclinical evidence for the potential of pterostilbene as a promising natural agent for MTA1-targeted interceptive strategy in future… read more here.
Keywords: mta1; cancer; pterostilbene; prostate cancer ... See more keywords
Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11802
Abstract: BACKGROUND/AIM Metastasis-associated gene 1 (MTA1) is considered a potential prognostic factor in esophageal cancer. We investigated the clinical relationship between MTA1, LAT1, and tumor metabolism, as evaluated by positron emission tomography (PET) in esophageal squamous… read more here.
Keywords: mta1 expression; cell carcinoma; squamous cell; expression ... See more keywords
MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00567
Abstract: Global incidence and mortality associated with hepatocellular carcinoma (HCC) is steadily increasing. Metastasis-associated 1 (MTA1) can induce tumorigenesis and metastatic progression in HCC. However, the mechanistic details of MTA1-mediated regulation of HCC has not been… read more here.
Keywords: phosphorylation; hcc; dna; mta1 ... See more keywords
Upregulation of MTA1 in Colon Cancer Drives A CD8+ T Cell-Rich But Classical Macrophage-Lacking Immunosuppressive Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.825783
Abstract: Background The MTA1 protein encoded by metastasis-associated protein 1 (MTA1) is a key component of the ATP-dependent nucleosome remodeling and deacetylase (NuRD) complex, which is widely upregulated in cancers. MTA1 extensively affects downstream gene expression… read more here.
Keywords: mta1; tumor microenvironment; colorectal cancer; tumor ... See more keywords