Melanoma susceptibility variant rs869330 in the MTAP gene is associated with melanoma outcome.
Sign Up to like & getrecommendations! Published in 2019 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000578
Abstract: The rising incidence of cutaneous melanoma (CM), an aggressive skin cancer, emphasizes the need for novel biomarkers to guide personalized care and better predict outcome. Genetic factors including germline risk variants are promising candidates for… read more here.
Keywords: melanoma; mtap gene; melanoma outcome; melanoma susceptibility ... See more keywords
Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts
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DOI: 10.1111/exd.13247
Abstract: Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding… read more here.
Keywords: mtap gene; risk alleles; risk; melanoma risk ... See more keywords