Mycobacterium tuberculosis causes a leaky blood‐brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10116
Abstract: The maternal system's exposure to pathogens influences foetal brain development through the influx of maternal cytokines and activation of the foetal immune status to a persistent inflammatory state characterised by glia cell activation. Neuroinflammation influences… read more here.
Keywords: blood brain; mtb; neuroinflammation; tuberculosis ... See more keywords
Comparative Study of GeneXpert MTB/RIF Assay and Multiplex PCR Assay for Direct Detection of Mycobacterium tuberculosis in Suspected Pulmonary Tuberculosis Patients
Sign Up to like & getrecommendations! Published in 2017 at "Current Microbiology"
DOI: 10.1007/s00284-017-1279-x
Abstract: Pulmonary tuberculosis (PTB) is one of the major infectious diseases in developing countries. The objective of this study was to compare rapid diagnostics technique, GeneXpert MTB/RIF (GeneXpert) and Multiplex PCR assay (MPCR) targeting IS6110 segment… read more here.
Keywords: pulmonary tuberculosis; mtb; study; genexpert ... See more keywords
Orientational dynamics of magnetotactic bacteria in Earth’s magnetic field—a simulation study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biological Physics"
DOI: 10.1007/s10867-021-09566-9
Abstract: We investigate through simulations the phenomena of magnetoreception to enable an understanding of the minimum requirements of a fail-safe mechanism, operational at the cellular level, to sense a weak magnetic field at ambient temperature in… read more here.
Keywords: magnetotactic bacteria; field; mtb; process ... See more keywords
Importance of differential identification of Mycobacterium tuberculosis strains for understanding differences in their prevalence, treatment efficacy, and vaccine development
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Microbiology"
DOI: 10.1007/s12275-018-8041-3
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to… read more here.
Keywords: mtb complex; treatment; mtb; complex strains ... See more keywords
Comparative lipidomics of drug sensitive and resistant Mycobacterium tuberculosis reveals altered lipid imprints
Sign Up to like & getrecommendations! Published in 2017 at "3 Biotech"
DOI: 10.1007/s13205-017-0972-6
Abstract: Lipids are most adaptable molecules that acclimatize to the development of multidrug resistance (MDR). The precise molecular mechanism of this acclimatization achieved in Mycobacterium tuberculosis (MTB) remains elusive. Although lipids of MTB have been characterized… read more here.
Keywords: mtb; drug sensitive; sensitive resistant; mycobacterium tuberculosis ... See more keywords
Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.11.037
Abstract: Summary Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this important pathogen in its primary human host cell, the macrophage, but little is known about the source(s) and their assimilation within… read more here.
Keywords: nitrogen; metabolism; mtb; tuberculosis ... See more keywords
Laboratory evaluation of the Anyplex™ II MTB/MDR and MTB/XDR tests based on multiplex real-time PCR and melting-temperature analysis to identify Mycobacterium tuberculosis and drug resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.08.016
Abstract: We evaluated the performance of two multiplex, real-time PCR tests (Anyplex II MTB/MDR and MTB/XDR; Seegene, Seoul, Korea), designed to detect the Mycobacterium tuberculosis complex (MTC) and drug-resistance mutations associated with isoniazid, rifampicin, fluoroquinolones, and… read more here.
Keywords: mtb xdr; mtb; mtb mdr; anyplex mtb ... See more keywords
Biodiversity of Magnetotactic Bacteria in the tropical marine environment of Singapore revealed by metagenomic analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental research"
DOI: 10.1016/j.envres.2021.110714
Abstract: Most studies on the diversity of magnetotactic bacteria (MTB) have been conducted on samples obtained from the Northern or the Southern hemispheres. The diversity of MTB in tropical Asia near the geo-equator, with a close-to-zero… read more here.
Keywords: marine environment; marine; mtb; tropical marine ... See more keywords
Antigen 85 complex as a powerful Mycobacterium tuberculosis immunogene: Biology, immune-pathogenicity, applications in diagnosis, and vaccine design.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.08.040
Abstract: Mycobacterium tuberculosis (Mtb) is one of the most life-threatening mycobacterial species which is increasing the death rate due to emerging multi-drug resistant (MDR) strains. Concerned health authorities worldwide are interested in developing an effective vaccine… read more here.
Keywords: vaccine; mtb; biology; mycobacterium tuberculosis ... See more keywords
WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.101891
Abstract: Fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis (Mtb), caused by amino acid substitutions in DNA gyrase, has been increasingly reported worldwide. WQ-3810 is a newly developed FQ that is highly active against FQ-resistant pathogens; however, its… read more here.
Keywords: mtb; tuberculosis; fluoroquinolone; activity ... See more keywords
HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection.
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DOI: 10.1016/j.tube.2021.102062
Abstract: RATIONALE Host-directed therapeutics for Mycobacterium tuberculosis (Mtb) offer potential strategies for combatting antibiotic resistance and for killing non-replicating bacilli. Phenylbutyrate, a partially selective histone-deacetylase (HDAC) inhibitor, was previously shown to control Mtb growth and alter… read more here.
Keywords: inhibitor; mtb; hdac3; growth ... See more keywords