Search for non-lactam inhibitors of mtb β-lactamase led to its open shape in apo state: new concept for antibiotic design
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DOI: 10.1038/s41598-017-06023-3
Abstract: Mtb β-lactamase (BlaC) is extremely efficient in hydrolyzing ß-lactam antibiotics which renders/leads to protection and/or resistance to this bug. There is a compelling need to develop new non-lactam inhibitors which can bind and inhibit BlaC,… read more here.
Keywords: shape; blac; mtb lactamase; open shape ... See more keywords