Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with Autoinflammatory Disease (SPAID)
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-3737-z
Abstract: BackgroundAutoinflammatory diseases in dogs are characterized by complex disease processes with varying clinical signs. In Shar-Pei, signs of inflammation including fever and arthritis are known to be related with a breed-specific predisposition for Shar-Pei Autoinflammatory… read more here.
Keywords: shar pei; spaid affected; disease; mtbp ... See more keywords
MDM2 Binding Protein Induces the Resistance of Hepatocellular Carcinoma Cells to Molecular Targeting Agents via Enhancing the Transcription Factor Activity of the Pregnane X Receptor
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.715193
Abstract: The MDM2 binding protein (MTBP) has been considered an important regulator of human malignancies. In this study, we demonstrate that the high level of MTBP’s endogenous expression is correlated with poor prognosis of advanced hepatocellular… read more here.
Keywords: hepatocellular carcinoma; mdm2 binding; hcc; mtbp ... See more keywords
The Role of MTBP as a Replication Origin Firing Factor
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DOI: 10.3390/biology11060827
Abstract: Simple Summary Copying the chromosomal DNA completely and faithfully during the process of DNA replication is key to inheriting the genetic information in an unaltered state. To achieve this, replication initiation, which generates the complex… read more here.
Keywords: replication; replication initiation; origin firing; initiation ... See more keywords
MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
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DOI: 10.3390/biology11060881
Abstract: Simple Summary Cancer is the second leading cause of death globally, accounting for approximately one in six deaths. Due to its critical role in cell growth/proliferation, one of the most well-known cancer-promoting proteins is MYC.… read more here.
Keywords: cell; proliferation; myc; human cancers ... See more keywords