MTDH in macrophages promotes the vasculogenic mimicry via VEGFA-165/Flt-1 signaling pathway in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107776
Abstract: Vasculogenic mimicry (VM) refers to vessel-like structures formed by aggressive tumor cells and is closely associated with cancer invasion and metastasis. Here, we investigated the effect of macrophage-derived MTDH on VM formation in head and… read more here.
Keywords: cell; 165 flt; vegfa 165; mac mtdh ... See more keywords
Breaking the oncogenic alliance: advances in disrupting the MTDH–SND1 complex for cancer therapy
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra04310g
Abstract: Metadherin (MTDH/AEG-1/LYRIC) partners with Staphylococcal Nuclease Domain-Containing Protein 1 (SND1) to form an oncogenic hub that drives proliferation, survival and metastasis in many tumors. Interrupting this interaction dampens pivotal pathways—including NF-κB, PI3K/Akt and Wnt/β-catenin—and simultaneously… read more here.
Keywords: breaking oncogenic; oncogenic alliance; mtdh; alliance advances ... See more keywords
MTDH promotes glioma invasion through regulating miR-130b-ceRNAs
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14717
Abstract: Cell invasion is crucial for high mortality and recurrence rate in glioma. Epithelial-mesenchymal transition (EMT) is an important step in cancer invasion. Metadherin (MTDH) contributes to EMT in several cancers, but the role and mechanism… read more here.
Keywords: glioma; invasion; like change; mtdh ... See more keywords
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19802
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a high metastatic potential. However, the mechanism of metastatic colonization in PDAC remains poorly understood. Metadherin (MTDH) has emerged in recent years as a crucial mediator of metastasis in several… read more here.
Keywords: cancer stem; pdac cells; metastasis; cancer ... See more keywords
Metadherin: A Therapeutic Target in Multiple Cancers
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00349
Abstract: Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in… read more here.
Keywords: expression; target multiple; mtdh; metadherin therapeutic ... See more keywords
Role of metadherin in estrogen-regulated gene expression
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2017.3020
Abstract: The disruption of estrogen signaling is widely associated with the development of breast, endometrial and ovarian cancers. As a multifunctional mediator of carcinogenesis, metadherin (MTDH)/astrocyte elevated gene-1 (AEG-1) overexpression has been associated with numerous types… read more here.
Keywords: breast; estrogen; gene expression; gene ... See more keywords
Metadherin regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Oncology"
DOI: 10.3892/ijo.2017.4002
Abstract: Metadherin (MTDH) can be recruited to mature tight junction complexes, and it regulates mesenchymal marker protein expression in many tumors and promote cancer metastasis. This study investigated the influence of MTDH expression on gastric cancer… read more here.
Keywords: gastric cancer; cancer metastasis; expression; cancer ... See more keywords
miR-3664-5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF-κB signaling pathway through targeting MTDH
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Oncology"
DOI: 10.3892/ijo.2019.4680
Abstract: Gastric cancer (GC) is one of the most common and fatal types of cancers worldwide and the specific mechanism has not been completely elucidated. microRNA (miR)‑3664‑5P has rarely been studied and the aim of the… read more here.
Keywords: proliferation metastasis; mir; mir 3664; signaling pathway ... See more keywords
Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6581
Abstract: Metadherin (MTDH) is a multifunctional oncogene involved in tumor cell migration and metastasis through regulating a number of oncogenic signaling pathways in various human malignancies. Previous studies have demonstrated that MTDH is overexpressed in human… read more here.
Keywords: cell; colorectal cancer; migration; expression ... See more keywords