Transition state analogue of MTAP extends lifespan of APCMin/+ mice
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DOI: 10.1038/s41598-021-87734-6
Abstract: A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5′-Methylthioadenosine (MTA), the substrate for MTAP,… read more here.
Keywords: mtdia; apcmin mice; mice; state analogue ... See more keywords