Mitochondrial DNA copy number in peripheral blood: a potential non-invasive biomarker for female subfertility
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-018-1291-5
Abstract: PurposeLow mitochondrial DNA (mtDNA) content in oocytes and in cumulus cells is an indicator of poor oocyte quality. Moreover, initial evidence showed a correlation between mtDNA content in cumulus cells and mtDNA copy number in… read more here.
Keywords: mtdna copy; number; copy number; peripheral blood ... See more keywords
SU24 POTENTIAL ALTERATIONS IN LEUKOCYTE MITOCHONDRIAL DNA COPY NUMBER FROM PATIENTS WITH BIPOLAR DISORDER TYPE I
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.213
Abstract: Background Mitochondrial dysfunction has been well documented in patients with Bipolar Disorder (BD). Studies demonstrated that alternations in mtDNA copy number have been associated with mitochondrial dysfunction and increased oxidative stress. However, association between mtDNA… read more here.
Keywords: copy number; dna; number; bipolar disorder ... See more keywords
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.
Sign Up to like & getrecommendations! Published in 2017 at "Mitochondrion"
DOI: 10.1016/j.mito.2017.02.001
Abstract: We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T… read more here.
Keywords: mtdna copy; copy number; organismal phenotype; copy ... See more keywords
+PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.03.013
Abstract: Mitochondrial DNA (mtDNA) copy number alterations occur in acute myeloid leukemia (AML). We evaluated regulation and biological significance of mtDNA copy number in pediatric AML patients (n=123) by qRT-PCR, and in-vitro studies. MtDNA copy number… read more here.
Keywords: copy number; number; acute myeloid; mtdna copy ... See more keywords
Blood cell respiration rates and mtDNA copy number: a promising tool for the diagnosis of mitochondrial disease.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.09.004
Abstract: Human mitochondrial diseases are a group of heterogeneous diseases caused by defects in oxidative phosphorylation, due to mutations in mitochondrial (mtDNA) or nuclear DNA. The diagnosis of mitochondrial disease is challenging since mutations in multiple… read more here.
Keywords: mitochondrial function; disease; number; diagnosis mitochondrial ... See more keywords
Mitochondrial DNA copy number variation - A potential biomarker for early onset preeclampsia.
Sign Up to like & getrecommendations! Published in 2020 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2020.10.002
Abstract: OBJECTIVES Oxidative stress has been hypothesized as a central component of both placental and endothelial dysfunction, leading to PE. This oxidative stress leading to mitochondrial dysfunction may be due to variations in mtDNA copy numbers… read more here.
Keywords: mtdna copy; early onset; copy number; copy ... See more keywords
Differential impacts of gonadotropins, IVF and embryo culture on mouse blastocyst development.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2019.02.007
Abstract: RESEARCH QUESTION Conception via Assisted Reproduction Technologies (ART) increases risk of Type 2 diabetes and cardiovascular disease in adulthood. Underlying differences between ART-conceived and in vivo-conceived embryos that contribute to this increased risk are not… read more here.
Keywords: number; mtdna copy; development; blastocyst ... See more keywords
The distinct spatiotemporal distribution and effect of feed restriction on mtDNA copy number in broilers
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60123-1
Abstract: Mitochondrial DNA (mtDNA) copy number reflects the abundance of mitochondria in cells and is dependent on the energy requirements of tissues. We hypothesized that the mtDNA copy number in poultry may change with age and… read more here.
Keywords: mtdna copy; restriction; number; copy number ... See more keywords
Autophagy determines mtDNA copy number dynamics during starvation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1532263
Abstract: ABSTRACT Derived from bacterial ancestors, mitochondria have maintained their own albeit strongly reduced genome, mitochondrial DNA (mtDNA), which encodes for a small and highly specialized set of genes. MtDNA exists in tens to thousands of… read more here.
Keywords: copy number; number dynamics; number; mtdna copy ... See more keywords
Mitochondrial DNA copy number in cumulus granulosa cells as a predictor for embryo morphokinetics and chromosome status
Sign Up to like & getrecommendations! Published in 2022 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2022.2145248
Abstract: Abstract While morphokinetic evaluation of embryos has become the most commonly used technique in IVF to select embryos for transfer, studies have demonstrated that mitochondrial DNA (mtDNA) copy number is correlated with embryo viability and… read more here.
Keywords: mtdna copy; number; mitochondrial dna; status ... See more keywords
Decrease of MtDNA copy number affects mitochondrial function and involves in the pathological consequences of ischaemic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17262
Abstract: The mtDNA copy number can affect the function of mitochondria and play an important role in the development of diseases. However, there are few studies on the mechanism of mtDNA copy number variation and its… read more here.
Keywords: group; mtdna copy; copy number;