Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2017.01.013
Abstract: Mutations in mitochondrial DNA (mtDNA) are maternally inherited and can cause fatal or debilitating mitochondrial disorders. The severity of clinical symptoms is often associated with the level of mtDNA mutation load or degree of heteroplasmy.… read more here.
Keywords: mtdna mutation; spindle transfer; transfer;
Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects
Sign Up to like & getrecommendations! Published in 2022 at "National Science Review"
DOI: 10.1093/nsr/nwac136
Abstract: Abstract Mitochondria are essential for female reproductive processes, yet the function of mitochondrial DNA (mtDNA) mutation in oocytes remains elusive. By employing an mtDNA mutator (Polgm) mouse model, we found the fetal growth retardation and… read more here.
Keywords: frequency oocytes; mtdna mutation; mutation frequency; increased mtdna ... See more keywords
A PI polyamide–TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.14912
Abstract: Mitochondrial DNA (mtDNA) mutations occur frequently in cancer cells, and some of them are often homoplasmic. Targeting such mtDNA mutations could be a new method for killing cancer cells with minimal impact on normal cells.… read more here.
Keywords: dna; mtdna mutation; cancer cells; cancer ... See more keywords
Suppression of NSCLC A549 tumor growth by a mtDNA mutation-targeting pyrrole-imidazole polyamide-TPP and a senolytic drug.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15290
Abstract: Certain somatic mutations in mitochondrial DNA (mtDNA) were associated with tumor progression and frequently found in a homoplasmic state. We recently reported that pyrrole-imidazole polyamide conjugated with the mitochondria-delivering moiety triphenylphosphonium (PIP-TPP) targeting a mtDNA… read more here.
Keywords: tumor; nsclc a549; mtdna mutation; pyrrole imidazole ... See more keywords
Aerobic Exercise Training in Patients With mtDNA-Related Mitochondrial Myopathy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00349
Abstract: In patients with mitochondrial DNA (mtDNA) mutation, a pathogenic mtDNA mutation is heteroplasmically distributed among tissues. The ratio between wild-type and mutated mtDNA copies determines the mtDNA mutation load of the tissue, which correlates inversively… read more here.
Keywords: patients mtdna; capacity; training; mtdna mutation ... See more keywords
Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032679
Abstract: In 25% of patients with mitochondrial myopathies, pathogenic mitochondrial DNA (mtDNA) mutation are the cause. For heteroplasmic mtDNA mutations, symptoms manifest when the mutation load exceeds a tissue-specific threshold. Therefore, lowering the mutation load is… read more here.
Keywords: mutation load; mtdna mutation; type mesoangioblasts; mutation ... See more keywords