Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10843-8
Abstract: Mitochondrial DNA (mtDNA) is organized in nucleoprotein complexes called mitochondrial nucleoids (mt-nucleoids), which are critical units of mtDNA replication and transmission. In humans, several hundreds of mt-nucleoids exist in a cell. However, how numerous mt-nucleoids… read more here.
Keywords: cycle; mtdna replication; mitochondrial nucleoids; cell cycle ... See more keywords
Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx443
Abstract: Abstract The mechanism of mitochondrial DNA (mtDNA) replication in Saccharomyces cerevisiae is controversial. Evidence exists for double-strand break (DSB) mediated recombination-dependent replication at mitochondrial replication origin ori5 in hypersuppressive ρ− cells. However, it is not… read more here.
Keywords: mtdna replication; bku; replication saccharomyces; evidence ... See more keywords
Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz047
Abstract: Abstract Newly synthesized mitochondrial RNA is concentrated in structures juxtaposed to nucleoids, called RNA granules, that have been implicated in mitochondrial RNA processing and ribosome biogenesis. Here we show that two classical mtDNA replication factors,… read more here.
Keywords: mtdna replication; replication factors; rna; rna granules ... See more keywords
Arabidopsis mitochondrial SSB1 and SSB2 are essential regulators of mtDNA replication and homologous recombination.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13338
Abstract: Faithful DNA replication is one of the most essential processes in almost all living organisms. However, the proteins responsible for organellar DNA replication are still largely unknown in plants. Here, we show that the two… read more here.
Keywords: dna; ssb1 ssb2; replication; ssb1 ... See more keywords