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   Articles with "mtdnacn" as a keyword



Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty

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recommendations! Published in 2024 at "GeroScience"

DOI: 10.1007/s11357-024-01355-1

Abstract: Mitochondrial dysfunction is linked to physical impairment and dementia. Mitochondrial DNA copy number (mtDNAcn) from blood may predict cognitive decline and dementia risk, but the effect of somatic mutations or frailty is unknown. We estimated… read more here.

Keywords: dementia; mutations frailty; mtdnacn; somatic mutations ... See more keywords

Effects of prenatal exposure to particulate air pollution on newborn mitochondrial DNA copy number.

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recommendations! Published in 2020 at "Chemosphere"

DOI: 10.1016/j.chemosphere.2020.126592

Abstract: Prenatal exposure to particulate matter (PM) in ambient air has been linked to changes in newborn mitochondrial DNA copy number (mtDNAcn), but the effects of exposure are inconsistent. We aimed to investigate the effect of… read more here.

Keywords: mtdnacn; exposure; exposure particulate; air ... See more keywords

Associations of urinary phthalate metabolites and lipid peroxidation with sperm mitochondrial DNA copy number and deletions

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recommendations! Published in 2018 at "Environmental Research"

DOI: 10.1016/j.envres.2018.01.023

Abstract: Background Phthalates, a chemical class of plasticizers, are ubiquitous environmental contaminants that have been associated with oxidative stress. Mitochondria DNA copy number (mtDNAcn) and DNA deletions (mtDNAdel) are emerging biomarkers for cellular oxidative stress and… read more here.

Keywords: urinary phthalate; mtdnacn; mtdnacn mtdnadel; phthalate ... See more keywords

Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposures, Newborn Mitochondrial DNA Copy Number, and the Modifying Role of the Maternal Folate Level.

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recommendations! Published in 2025 at "Environmental science & technology"

DOI: 10.1021/acs.est.5c06494

Abstract: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may damage newborn mitochondrial function indicated by lower mitochondrial DNA copy number (mtDNAcn), which may help explain the mechanisms underlying adverse health outcomes in offspring. Adequate maternal… read more here.

Keywords: folate; mtdnacn; substances pfas; per polyfluoroalkyl ... See more keywords

Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study

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recommendations! Published in 2017 at "American Journal of Epidemiology"

DOI: 10.1093/aje/kwx183

Abstract: Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events,… read more here.

Keywords: lifetime stress; mtdnacn; copy number; dna copy ... See more keywords

Mitochondrial DNA copy number in peripheral blood leukocytes is associated with biochemical recurrence in prostate cancer patients in African Americans.

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recommendations! Published in 2019 at "Carcinogenesis"

DOI: 10.1093/carcin/bgz139

Abstract: Mitochondria play multiple important cellular functions. The purpose of this study was to evaluate whether leukocyte mitochondrial DNA copy number (mtDNAcn) is associated with aggressive prostate cancer (PCa) in African American (AA) men. We measured… read more here.

Keywords: mtdnacn; copy number; prostate cancer; dna copy ... See more keywords

Pre-diagnostic Leukocyte Mitochondrial DNA Copy Number and Colorectal Cancer Risk.

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recommendations! Published in 2019 at "Carcinogenesis"

DOI: 10.1093/carcin/bgz159

Abstract: Mitochondrial DNA (mtDNA) is susceptible to oxidative stress and mutation. Few epidemiological studies have assessed the relationship between mtDNA copy number (mtDNAcn) and risk of colorectal cancer (CRC), with inconsistent findings. In this study, we… read more here.

Keywords: mtdnacn; risk; pre diagnostic; diagnostic leukocyte ... See more keywords

Genome-wide association study of mitochondrial copy number.

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recommendations! Published in 2021 at "Human molecular genetics"

DOI: 10.1093/hmg/ddab341

Abstract: Mitochondrial DNA copy number (mtDNAcn) variation has been associated with increased risk of several human diseases in epidemiological studies. The quantification of mtDNAcn performed with real-time PCR is currently considered the de facto standard among… read more here.

Keywords: association study; wide association; mtdnacn; genome wide ... See more keywords

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

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recommendations! Published in 2021 at "Molecular Neurodegeneration"

DOI: 10.1186/s13024-021-00495-8

Abstract: Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been associated with neurodegenerative diseases and… read more here.

Keywords: mtdnacn; alzheimer disease; cognitive function; mitochondrial dna ... See more keywords

Effects of different feeding levels during a 14-week preweaning phase in dairy heifer calves on telomere length and mitochondrial DNA copy number in blood.

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recommendations! Published in 2022 at "Journal of dairy science"

DOI: 10.3168/jds.2022-21891

Abstract: Telomeres cap the ends of eukaryotic chromosomes, and the telomere length (TL) is related to cellular age. The mitochondrial DNA copy number (mtDNAcn) reflects the abundance of mitochondria in a cell. In addition to generating… read more here.

Keywords: telomere length; age; mitochondrial dna; life ... See more keywords

Pathogenetic and Prognostic Implications of Increased Mitochondrial Content in Multiple Myeloma

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recommendations! Published in 2021 at "Cancers"

DOI: 10.3390/cancers13133189

Abstract: Simple Summary Monoclonal gammopathies comprise a spectrum of disorders defined by the clonal proliferation of plasma cells and include monoclonal gammopathy of undetermined significance (MGUS), smoldering MM (SMM) and multiple myeloma (MM), which can also… read more here.

Keywords: mtdnacn; monoclonal gammopathies; myeloma; smm ... See more keywords