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Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126592
Abstract: Prenatal exposure to particulate matter (PM) in ambient air has been linked to changes in newborn mitochondrial DNA copy number (mtDNAcn), but the effects of exposure are inconsistent. We aimed to investigate the effect of…
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Keywords:
mtdnacn;
exposure;
exposure particulate;
air ... See more keywords
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Published in 2018 at "Environmental Research"
DOI: 10.1016/j.envres.2018.01.023
Abstract: Background Phthalates, a chemical class of plasticizers, are ubiquitous environmental contaminants that have been associated with oxidative stress. Mitochondria DNA copy number (mtDNAcn) and DNA deletions (mtDNAdel) are emerging biomarkers for cellular oxidative stress and…
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Keywords:
urinary phthalate;
mtdnacn;
mtdnacn mtdnadel;
phthalate ... See more keywords
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Published in 2017 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwx183
Abstract: Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events,…
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Keywords:
lifetime stress;
mtdnacn;
copy number;
dna copy ... See more keywords
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Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz139
Abstract: Mitochondria play multiple important cellular functions. The purpose of this study was to evaluate whether leukocyte mitochondrial DNA copy number (mtDNAcn) is associated with aggressive prostate cancer (PCa) in African American (AA) men. We measured…
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Keywords:
mtdnacn;
copy number;
prostate cancer;
dna copy ... See more keywords
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Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz159
Abstract: Mitochondrial DNA (mtDNA) is susceptible to oxidative stress and mutation. Few epidemiological studies have assessed the relationship between mtDNA copy number (mtDNAcn) and risk of colorectal cancer (CRC), with inconsistent findings. In this study, we…
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Keywords:
mtdnacn;
risk;
pre diagnostic;
diagnostic leukocyte ... See more keywords
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Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab341
Abstract: Mitochondrial DNA copy number (mtDNAcn) variation has been associated with increased risk of several human diseases in epidemiological studies. The quantification of mtDNAcn performed with real-time PCR is currently considered the de facto standard among…
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Keywords:
association study;
wide association;
mtdnacn;
genome wide ... See more keywords
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Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00495-8
Abstract: Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been associated with neurodegenerative diseases and…
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Keywords:
mtdnacn;
alzheimer disease;
cognitive function;
mitochondrial dna ... See more keywords
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Published in 2022 at "Journal of dairy science"
DOI: 10.3168/jds.2022-21891
Abstract: Telomeres cap the ends of eukaryotic chromosomes, and the telomere length (TL) is related to cellular age. The mitochondrial DNA copy number (mtDNAcn) reflects the abundance of mitochondria in a cell. In addition to generating…
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Keywords:
telomere length;
age;
mitochondrial dna;
life ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13133189
Abstract: Simple Summary Monoclonal gammopathies comprise a spectrum of disorders defined by the clonal proliferation of plasma cells and include monoclonal gammopathy of undetermined significance (MGUS), smoldering MM (SMM) and multiple myeloma (MM), which can also…
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Keywords:
mtdnacn;
monoclonal gammopathies;
myeloma;
smm ... See more keywords