Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
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DOI: 10.1002/1873-3468.14611
Abstract: Human MutT homolog 1 (MTH1), also known as Nudix type motif 1 (NUDT1), hydrolyzes 8-oxo-dGTP and 2-oxo-dATP with broad substrate recognition and has attracted attention in anti-cancer therapeutics. Previous studies on MTH1 have proposed that… read more here.
Keywords: recognition; mth1; protonation; broad substrate ... See more keywords
MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?☆
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DOI: 10.1016/j.freeradbiomed.2016.11.002
Abstract: &NA; 8‐Oxo‐7,8‐dihydroguanine (GO) can originate as 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine 5′‐triphosphate (8‐oxo‐dGTP), an oxidized form of dGTP in the nucleotide pool, or by direct oxidation of guanine base in DNA. Accumulation of GO in cellular genomes can result… read more here.
Keywords: accumulation; oxo dgtp; mth1; nucleotide pool ... See more keywords
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
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DOI: 10.1021/acschembio.7b00370
Abstract: MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool compounds published in the literature inhibited the enzymatic activity of MTH1 and subsequently induced… read more here.
Keywords: mth1; target; class potent; novel class ... See more keywords
Visualizing the three-metal-ion-dependent cleavage of a mutagenic nucleotide
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DOI: 10.1073/pnas.2207180119
Abstract: The accurate replication, transcription, and maintenance of genetic material requires housekeeping enzymes that prevent the spontaneous mutagenesis of DNA by catalyzing the removal of oxidized deoxynucleoside triphosphates (dNTPs). These include the Nudix hydrolase superfamily member… read more here.
Keywords: metal ion; visualizing three; mth1; oxo dgtp ... See more keywords
Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1
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DOI: 10.1158/1538-7445.am2018-689
Abstract: Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular. 8-oxo-29-deoxyguanosine-59-triphosphate (8-oxo-dGTP) and 2-hydroxydeoxyadenosine-59-triphosphate (2-OH-dATP) are the two most abundant oxidative nucleotide lesions in this… read more here.
Keywords: chemical matter; structure based; mth1; novel chemical ... See more keywords
Abstract IA12: Poisoning cancer with oxidized nucleotides by targeting MTH1
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DOI: 10.1158/1557-3125.dnarepair16-ia12
Abstract: DNA damaging agents, i.e., radio- and chemotherapy, constitute the backbone for treatment of a wide variety of cancers and may result in complete cure from the disease. Here, I will give an overview on how… read more here.
Keywords: cancer; dna damage; mth1; cancer cells ... See more keywords
Karonudib is a promising anticancer therapy in hepatocellular carcinoma
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DOI: 10.1177/1758835919866960
Abstract: Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is generally caused by viral infections or consumption of mutagens, such as alcohol. While liver transplantation and hepatectomy is curative for some… read more here.
Keywords: hepatocellular carcinoma; karonudib promising; hcc; mth1 ... See more keywords
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
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DOI: 10.3892/ol.2018.8812
Abstract: Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to… read more here.
Keywords: mth1; group; ogg1 mth1; expression ... See more keywords