LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "mthfd2" as a keyword



Photo by ricbro from unsplash

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.

Sign Up to like & get
recommendations! Published in 2019 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.9b00069

Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-selective MTHFD2 inhibitor is… read more here.

Keywords: mthfd2 inhibitor; mthfd2; selective mthfd2; isozyme selective ... See more keywords
Photo from wikipedia

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjac020

Abstract: Abstract Folate metabolism plays an essential role in tumor development. Various cancers display therapeutic response to reagents targeting key enzymes of the folate cycle, but obtain chemoresistance later. Therefore, novel targets in folate metabolism are… read more here.

Keywords: metabolism; cell; growth; folate metabolism ... See more keywords
Photo by nhiamoua from unsplash

MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK‐3β/β‐catenin signalling

Sign Up to like & get
recommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.16715

Abstract: Recent studies have demonstrated that one‐carbon metabolism plays a significant role in cancer development. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme of one‐carbon metabolism, has been reported to be dysregulated in many cancers. However, the… read more here.

Keywords: lung adenocarcinoma; luad; mthfd2; metastasis ... See more keywords
Photo by ospanali from unsplash

ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis

Sign Up to like & get
recommendations! Published in 2022 at "Disease Markers"

DOI: 10.1155/2022/7527996

Abstract: Purpose Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been reported to be overexpressed in non-small-cell lung cancer (NSCLC) and to correlate with malignant proliferation. However, the mechanism of high MTHFD2 expression in NSCLC has not been clarified.… read more here.

Keywords: nsclc progression; atf4 myc; expression; myc ... See more keywords
Photo by 20164rhodi from unsplash

Abstract 3913: Genomic loss of UQCR11 creates therapeutic vulnerability in triple-negative breast cancer

Sign Up to like & get
recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3913

Abstract: Recurrent loss-of-function deletions are prevalent genomic alterations in tumors; nonetheless, these deletions occasionally create conditional therapeutic vulnerabilities in tumors. Our previous study used The Cancer Genome Atlas High-Grade Serous Ovarian Carcinoma (TCGA-HGSOC) dataset to identify… read more here.

Keywords: breast cancer; mthfd2; loss uqcr11; cancer ... See more keywords
Photo from wikipedia

Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma

Sign Up to like & get
recommendations! Published in 2021 at "International Journal of General Medicine"

DOI: 10.2147/ijgm.s323858

Abstract: Objective This study aimed to reveal the potential function of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and emphasized its importance in brain low-grade glioma (LGG). Methods We firstly explored the differential expression of MTHFD2 mRNA in LGG… read more here.

Keywords: expression; dehydrogenase mthfd2; methylenetetrahydrofolate dehydrogenase; mthfd2 ... See more keywords

Identification of MTHFD2 as a prognostic biomarker and ferroptosis regulator in triple-negative breast cancer

Sign Up to like & get
recommendations! Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1098357

Abstract: Background Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme encoded in the nucleus. It plays a significant role in the regulation of glucose, nucleic acid, and folate metabolism, and maintains redox balance in the… read more here.

Keywords: triple negative; expression; breast cancer; mthfd2 ... See more keywords