Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
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DOI: 10.1021/acsmedchemlett.9b00069
Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-selective MTHFD2 inhibitor is… read more here.
Keywords: mthfd2 inhibitor; mthfd2; selective mthfd2; isozyme selective ... See more keywords