The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
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DOI: 10.1002/cmdc.202200274
Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial 1‐carbon metabolism enzyme, which is an attractive anticancer drug target as it is highly upregulated in cancer but is not expressed in healthy adult cells. Selective MTHFD2 inhibitors… read more here.
Keywords: mthfd2l; isoform selective; structure; structure human ... See more keywords