The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
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DOI: 10.1002/cmdc.202200274
Abstract: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial 1‐carbon metabolism enzyme, which is an attractive anticancer drug target as it is highly upregulated in cancer but is not expressed in healthy adult cells. Selective MTHFD2 inhibitors… read more here.
Keywords: mthfd2l; isoform selective; structure; structure human ... See more keywords
Selectivity analysis of diaminopyrimidine-based inhibitors of MTHFD1, MTHFD2 and MTHFD2L
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DOI: 10.1038/s41598-024-71879-1
Abstract: The mitochondrial enzyme methylenetetrahydrofolate dehydrogenase (MTHFD2) is involved in purine and thymidine synthesis via 1C metabolism. MTHFD2 is exclusively overexpressed in cancer cells but absent in most healthy adult human tissues. However, the two close… read more here.
Keywords: inhibitors mthfd2; mthfd2l; mthfd1 mthfd2; based inhibitors ... See more keywords