MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements
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DOI: 10.1515/dmpt-2021-0219
Abstract: Abstract Objectives The fluoropyrimidine derivatives 5-Fluorouracil and Capecitabine are widely used for the treatment of solid tumors. Fluoropyrimidine metabolism involves a cascade of different enzymes, including MTHFR enzyme. MTHFR c.665C>T polymorphism, leading to decreased MTHFR… read more here.
Keywords: dose reduction; therapy; mthfr 665c; fluoropyrimidine ... See more keywords