Variants c.677 C>T, c.1298 A>C in MTHFR, and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women
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DOI: 10.1089/gtmb.2020.0106
Abstract: Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL),… read more here.
Keywords: mtrr 66a; chinese women; rpl; mtrr ... See more keywords
MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico
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DOI: 10.1089/gtmb.2023.0690
Abstract: Background: Several studies in mothers of infants with Down syndrome (DS) (MoIDS) have suggested that the 677C>T and 1298A>C variants of the 5,10-methylentetrahydrofolate reductase (MTHFR) gene can increase the risk of having a child with… read more here.
Keywords: mthfr 677c; mothers infants; 677c 1298a; western mexico ... See more keywords
Distribution of Methylene Tetrahydrofolate Reductase Gene Polymorphisms in Women of Childbearing Age in Tai'an
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DOI: 10.1155/ijog/8889232
Abstract: Objective: The objective was to explore the distribution characteristics of methylenetetrahydrofolate reductase MTHFR 677C > T and 1298A > C gene polymorphisms among women of childbearing age in the Tai'an area. Method: A total of 243 women of childbearing… read more here.
Keywords: age; mthfr 677c; gene polymorphisms; childbearing age ... See more keywords
Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort
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DOI: 10.1289/ehp14479
Abstract: Background: Folic acid (FA) supplementation may attenuate the associations between gestational exposure to certain chemicals and autism or autistic-like behaviors, but to our knowledge, this has not been assessed for lead. Objectives: We examined whether… read more here.
Keywords: pregnancy birth; like behaviors; autistic like; mthfr 677c ... See more keywords
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes
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DOI: 10.1371/journal.pone.0182472
Abstract: Background DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with… read more here.
Keywords: methylation; homocysteine; elevated homocysteine; mthfr 677c ... See more keywords
Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis
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DOI: 10.1371/journal.pone.0271170
Abstract: Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate… read more here.
Keywords: meta analysis; mthfr 677c; analysis; 677c 1298a ... See more keywords
Association of ABCB1 and MTHFR genetic polymorphisms with rheumatoid arthritis susceptibility in a Chinese population
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DOI: 10.3389/fmed.2025.1660473
Abstract: Objective The present study aimed to investigate the association of the ATP-binding cassette subfamily B member 1 (ABCB1) 3435C/T and methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C polymorphisms with susceptibility to RA and RA subtype. Methods… read more here.
Keywords: mthfr 677c; susceptibility; abcb1 3435c; association ... See more keywords
Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
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DOI: 10.3389/fphar.2018.01390
Abstract: Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes of methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China. Materials and Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) and 1298A>C… read more here.
Keywords: rheumatoid arthritis; mtr; mthfr 677c; therapy rheumatoid ... See more keywords
Association of MTHFR 677C>T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation.
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DOI: 10.5582/bst.2021.01306
Abstract: Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphism rs1801133 (677C>T) will decrease the utilization of folate. Folate deficiency and its resulting homocysteine (HCY) accumulation can impair female fertility. Folic acid (FA) supplementation is necessary in pregnant women who… read more here.
Keywords: supplementation; polymorphism; mthfr 677c; pregnancy outcomes ... See more keywords