Variants c.677 C>T, c.1298 A>C in MTHFR, and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women
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DOI: 10.1089/gtmb.2020.0106
Abstract: Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL),… read more here.
Keywords: mtrr 66a; chinese women; rpl; mtrr ... See more keywords
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes
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DOI: 10.1371/journal.pone.0182472
Abstract: Background DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with… read more here.
Keywords: methylation; homocysteine; elevated homocysteine; mthfr 677c ... See more keywords
Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis
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DOI: 10.1371/journal.pone.0271170
Abstract: Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate… read more here.
Keywords: meta analysis; mthfr 677c; analysis; 677c 1298a ... See more keywords
Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
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DOI: 10.3389/fphar.2018.01390
Abstract: Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes of methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China. Materials and Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) and 1298A>C… read more here.
Keywords: rheumatoid arthritis; mtr; mthfr 677c; therapy rheumatoid ... See more keywords
Association of MTHFR 677C>T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation.
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DOI: 10.5582/bst.2021.01306
Abstract: Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphism rs1801133 (677C>T) will decrease the utilization of folate. Folate deficiency and its resulting homocysteine (HCY) accumulation can impair female fertility. Folic acid (FA) supplementation is necessary in pregnant women who… read more here.
Keywords: supplementation; polymorphism; mthfr 677c; pregnancy outcomes ... See more keywords