Abstract LB192: MTL-CEBPA in combination with pembrolizumab converts an immune desert to an inflamed TME in solid tumors resistant to checkpoint blockade
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DOI: 10.1158/1538-7445.am2023-lb192
Abstract: Despite significant advances in outcomes with immunotherapy, most cancer patients do not benefit from currently approved immune checkpoint inhibitors (ICI). The reasons for ICI resistance are multi-faceted and suggest that additional immunomodulation is required to… read more here.
Keywords: cebpa; inflamed tme; mtl cebpa; combination ... See more keywords
Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma
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DOI: 10.2174/1389201019666180611093428
Abstract: Background: Oligonucleotide drug development has revolutionised the drug discovery field. Within this field, ‘small’ or ‘short’ activating RNAs (saRNA) are a more recently discovered category of short double-stranded RNA with clinical potential. saRNAs promote transcription… read more here.
Keywords: drug; development mtl; mtl cebpa; carcinoma ... See more keywords