Live cell imaging of lytic granule motility in anti-ErbB2 CAR NK cells and FcR NK cells plus Herceptin towards ErbB2+ breast cancer cells
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DOI: 10.1016/j.jcyt.2020.04.068
Abstract: Background & Aim Upon encountering a susceptible target, NK cells mediate directed cytotoxicity by exocytosis of lytic effector molecules such as perforin and granzymes. The steps leading to NK cell granule exocytosis are highly regulated.… read more here.
Keywords: live cell; mtoc; towards erbb2; cell ... See more keywords
Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation
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DOI: 10.1242/bio.036822
Abstract: ABSTRACT Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also major… read more here.
Keywords: malaria parasite; mtoc; proliferation; plasmodium ... See more keywords
PEDF regulates plasticity of a novel lipid–MTOC axis in prostate cancer-associated fibroblasts
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DOI: 10.1242/jcs.213579
Abstract: ABSTRACT Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, to sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs) undergo metabolic re-programming. We… read more here.
Keywords: lipid mtoc; mtoc axis; mtoc; pedf ... See more keywords
Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites
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DOI: 10.7554/elife.56547
Abstract: A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. Conserved among both invertebrates and vertebrates, axons contain exclusively ‘plus-end-out’ microtubules while dendrites contain a high percentage of ‘minus-end-out’… read more here.
Keywords: mtoc; growth cone; microtubule; end microtubules ... See more keywords