A novel mTOR-associated gene signature for predicting prognosis and evaluating tumor immune microenvironment in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105394
Abstract: BACKGROUND The mechanistic target of rapamycin (mTOR) was proven to have great impact on apoptosis, cell proliferation, autophagy, and many other fundamental cellular processes; moreover, it closely correlates with tumor occurrence and development. However, few… read more here.
Keywords: analysis; associated gene; signature; mtor associated ... See more keywords
eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23136932
Abstract: Aberrantly activated mechanistic target of rapamycin (mTOR) signaling pathway stimulates translation initiation/protein synthesis and eventually causes tumors. Targeting these processes thus holds potential for treating mTOR-associated diseases. We tested the potential of eFT226, a sequence-selective… read more here.
Keywords: hyperactive mtor; inhibitor; mtor associated; inducing necroptosis ... See more keywords