Metformin inhibits mTOR–HIF‐1α axis and profibrogenic and inflammatory biomarkers in thioacetamide‐induced hepatic tissue alterations
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DOI: 10.1002/jcp.27616
Abstract: The potential inhibitory effect of the antidiabetic and anti‐inflammatory drug, metformin on thioacetamide (TAA)‐induced hepatotoxicity associated with the inhibition of mammalian target of rapamycin (mTOR)–hypoxia‐inducible factor‐1α (HIF‐1α) axis has not been investigated before. Therefore, we… read more here.
Keywords: mtor hif; axis profibrogenic; inflammatory; mtor ... See more keywords
Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
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DOI: 10.1016/j.isci.2021.102521
Abstract: Summary Lipotoxicity plays an important role in the development of diabetic heart failure (HF). Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly beneficial effects on HF. In this study, we evaluated the protective… read more here.
Keywords: lipotoxicity cardiomyocytes; hif pathway; lipotoxicity; mtor hif ... See more keywords
Caffeic acid inhibits Staphylococcus aureus‐induced endometritis through regulating AMPKα/mTOR/HIF‐1α signalling pathway
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DOI: 10.1111/jcmm.70175
Abstract: Endometritis is mostly caused by childbirth or postpartum uterine infection. It is one of the important reasons leading to female infertility. Caffeic acid (CA) and its derivatives are widely found in some foods and traditional… read more here.
Keywords: aureus induced; mtor hif; ampk mtor; induced endometritis ... See more keywords
Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
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DOI: 10.18632/oncotarget.16500
Abstract: Pediatric high grade glioma (pHGGs), including sus-tentorial and diffuse intrinsic pontine gliomas, are known to have a very dismal prognosis. For instance, even an increased knowledge on molecular biology driving this brain tumor entity, there… read more here.
Keywords: pediatric high; hif; gliomas; high grade ... See more keywords