mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double‐Blind, Placebo‐Controlled Futility Trial and 1‐Year Biomarker Longitudinal Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28923
Abstract: Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by the aggregation of α‐synuclein in glia and neurons. Sirolimus (rapamycin) is an mTOR inhibitor that promotes α‐synuclein autophagy and reduces its associated neurotoxicity in… read more here.
Keywords: system atrophy; multiple system; mtor inhibition; inhibition sirolimus ... See more keywords
Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9470-9
Abstract: Mammalian target of rapamycin (mTOR), a serine/threonine kinase orchestrating cellular metabolism, is a crucial immune system regulator. However, it remains unclear how mTOR regulates dendritic cell (DC) function in vivo, especially DC-T cell encounters, a… read more here.
Keywords: mtor inhibition; inhibition; cell encounters; morphology ... See more keywords
mTOR inhibition: a double-edged sword in patients with COVID-19?
Sign Up to like & getrecommendations! Published in 2021 at "Human Cell"
DOI: 10.1007/s13577-021-00495-2
Abstract: The current COVID-19 is one of the deadliest pandemics in recent decades. In the lack of a specific treatment for this novel infection, knowing the role of cell signaling pathways in the pathogenesis of this… read more here.
Keywords: cell; mtor inhibition; inhibition double; mtor ... See more keywords
Phosphoproteome Profiling Revealed the Importance of mTOR Inhibition on CDK1 Activation to Further Regulate Cell Cycle Progression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00848
Abstract: The mammalian target of rapamycin (mTOR) functions as a critical regulator of cell cycle progression. However, the underlying mechanism by which mTOR regulates cell cycle progression remains elusive. In this study, we used stable isotope… read more here.
Keywords: mtor inhibition; mtor; cell cycle;
mTOR Inhibition and Clinical Transplantation: Kidney.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000001692
Abstract: T mammalian target of rapamycin (mTOR) inhibitor class of immunosuppressive drugs were introduced more than 15 years ago as a new opportunity to create selective antirejection therapy in solid organ transplantation. In particular, absence of… read more here.
Keywords: clinical transplantation; inhibition clinical; mtor inhibition; transplantation ... See more keywords
mTOR Inhibition and Kidney Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000001729
Abstract: Abstract Mammalian or mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that plays essential roles in cell growth, proliferation, metabolism, and survival. Increased activation of the mTOR pathway is observed in patients and animal… read more here.
Keywords: kidney diseases; mtor inhibition; inhibition kidney; mtor ... See more keywords
mTOR Inhibition and Clinical Transplantation: Heart.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000001921
Abstract: This brief overview discusses recent data on the use of mammalian target of rapamycin (mTOR) inhibitors in heart transplantation. Trials on de novo use have shown good efficacy of mTOR inhibitors; however, adverse events are… read more here.
Keywords: heart; clinical transplantation; inhibition clinical; mtor inhibition ... See more keywords
Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13304
Abstract: Stem cell transplantation has been generally considered as promising therapeutics in preserving or recovering functions of lost, damaged, or aging tissues. Transplantation of primordial germ cells (PGCs) or oogonia stem cells (OSCs) can reconstitute ovarian… read more here.
Keywords: mtor inhibition; inhibition ink128; mtor; stem ... See more keywords
107 Metabolic reprogramming to enhance the efficacy of mtor inhibition in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2017-000663.107
Abstract: Purpose of study PI3K/mTOR pathway is mutated in 10%–20% of colorectal cancer (CRC) specimens and has been associated with poor survival. In this study, we found diacylglycerol kinase (DGK), involved in lipid signalling, to be… read more here.
Keywords: dgk; mtor inhibition; tak 228; inhibition ... See more keywords
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-0803
Abstract: Purpose: Glioblastoma (GBM) is a deadly brain tumor marked by dysregulated signaling and aberrant cell-cycle control. Molecular analyses have identified that the CDK4/6-Rb-E2F axis is dysregulated in about 80% of GBMs. Single-agent CDK4/6 inhibitors have… read more here.
Keywords: combined cdk4; glioblastoma; mtor inhibition; inhibition ... See more keywords
Manganese-enhanced MRI depicts a reduction in brain responses to nociception upon mTOR inhibition in chronic pain rats
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00687-1
Abstract: Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Although cerebral activities… read more here.
Keywords: mtor inhibition; brain; chronic pain; pain ... See more keywords