Abstract 5894: Snail reduces the antitumor efficacy of mTOR kinase inhibitors by transcriptional repression of 4E-BP1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5894
Abstract: The mTOR inhibitors, including the second generation of mTOR kinase inhibitors, for cancer treatment have been evaluated in clinical trials, but their overall activity as monotherapy is limited. The cap-dependent translation repressor, 4E-BP1, is an… read more here.
Keywords: kinase inhibitors; bp1; snail; mtor ... See more keywords
Abstract 660: Combination of mTOR kinase inhibitors with Src inhibitors in PTEN-mtprostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-660
Abstract: Although Src inhibitors are able to suppress malignant functions, their clinical outcomes are modest for the treatment of advanced prostate cancer, many of which harbor mutated PTEN. mTOR pathway is commonly hyperactivated in prostate cancer… read more here.
Keywords: src inhibitors; prostate cancer; mtor; cancer ... See more keywords
Possible Mechanism of Human Recombinant Leptin-Induced VEGF A Synthesis via PI3K/Akt/mTOR/S6 Kinase Signaling Pathway while Inducing Angiogenesis: An Analysis Using Chicken Chorioallantoic Membrane Model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of vascular research"
DOI: 10.1159/000516498
Abstract: INTRODUCTION The present study aimed to realize human recombinant leptin 's ability to synthesize VEGF A while inducing neovascularization through PI3K/Akt/mTOR/S6 kinase involved signaling pathway. METHODS To examine the PI3K/Akt/mTOR/S6 kinase pathway involvement in leptin-induced… read more here.
Keywords: human recombinant; leptin; pi3k akt; recombinant leptin ... See more keywords
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s208720
Abstract: Purpose This first-in-human Phase I study investigated the safety, pharmacokinetics (PK), pharmacodynamic profile, and preliminary efficacy of CC-115, a dual inhibitor of mammalian target of rapamycin (mTOR) kinase and DNA-dependent protein kinase. Patients and Methods… read more here.
Keywords: kinase; first human; mtor; mtor kinase ... See more keywords