Intermittent pulsed electromagnetic field stimulation activates the mTOR pathway and stimulates the proliferation of osteoblast-like cells.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectromagnetics"
DOI: 10.1002/bem.22207
Abstract: Pulsed electromagnetic fields (PEMFs) have been shown to be a noninvasive physical stimulant for bone fracture healing. However, PEMF stimulation requires a relatively long period of time and its mechanism of action has not yet… read more here.
Keywords: mtor pathway; stimulation; proliferation; pemf stimulation ... See more keywords
PTEN expression and mutations in TSC1, TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32579
Abstract: The mammalian target of rapamycin (mTOR) pathway inhibitors are key drugs for the treatment of many tumor types, however, there are no predictive biomarkers in clinical use. Here, we performed a molecular and immunohistochemical characterization… read more here.
Keywords: mtor pathway; renal cell; response; cell carcinoma ... See more keywords
Titanium dioxide nanoparticles induce apoptosis through ROS‐Ca2+‐p38/AKT/mTOR pathway in TM4 cells
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4583
Abstract: Titanium dioxide nanoparticles (TiO2 NPs) can cause apoptosis in TM4 cells; however, the underlying mechanism has not been entirely elucidated. The purpose of this study was to investigate the effects of TiO2 NPs on ROS,… read more here.
Keywords: akt mtor; p38 akt; apoptosis; tio2 nps ... See more keywords
Asperuloside alleviates cyclophosphamide‐induced myelosuppression by promoting AMPK/mTOR pathway‐mediated autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23641
Abstract: Cyclophosphamide (CTX) is a common anticancer chemotherapy drug, and myelosuppression is the most common serious side effect. Asperuloside (ASP), the active component of Hedyotis diffusa Willd., may have the effect of ameliorating chemotherapy‐induced myelosuppression. This… read more here.
Keywords: ctx; myelosuppression; mtor pathway; induced myelosuppression ... See more keywords
RRM2 Is a Putative Biomarker and Promotes Bladder Cancer Progression via PI3K/AKT/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31501
Abstract: Bladder cancer (BLCA) is the tenth most common cancer worldwide, characterized by its high recurrence and progression rates. Thus, identifying prognostic biomarkers and understanding its underlying mechanisms are imperative to enhance patient outcomes. In this… read more here.
Keywords: cancer; akt mtor; progression; rrm2 ... See more keywords
α‐enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22603
Abstract: The α‐enolase (ENO1) plays pivotal roles in several types of cancer, but its clinical significance, functional role, and possible mechanism in colorectal cancer (CRC) have remained unclear. Expression level of ENO1 in CRC tissues was… read more here.
Keywords: mtor pathway; ampk mtor; mtor; eno1 ... See more keywords
PDZ‐binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23519
Abstract: The therapeutic effects of existing drug regimens against pancreatic neuroendocrine neoplasms (pNENs) remain limited, and identifying ideal therapeutic targets is warranted. PDZ binding kinase (PBK) may play an oncogenic role in most solid tumors. However,… read more here.
Keywords: akt mtor; pancreatic neuroendocrine; mtor pathway; pnen ... See more keywords
Genetic basis and imaging findings of neurofibromatosis 1 and other somatic overgrowth disorders
Sign Up to like & getrecommendations! Published in 2024 at "Skeletal Radiology"
DOI: 10.1007/s00256-024-04772-7
Abstract: Somatic overgrowth disorders comprise a wide range of rare conditions that present with focal enlargement of one or more tissue types. The PI3K-AKT-mTOR pathway is a signalling pathway that induces angiogenesis and cell proliferation, and… read more here.
Keywords: overgrowth; somatic overgrowth; akt mtor; overgrowth disorders ... See more keywords
The host mTOR pathway and parasitic diseases pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology Research"
DOI: 10.1007/s00436-021-07070-6
Abstract: The mechanistic (or mammalian) target of rapamycin (mTOR) is considered as a critical regulatory enzyme involved in essential signaling pathways affecting cell growth, cell proliferation, protein translation, regulation of cellular metabolism, and cytoskeletal structure. Also,… read more here.
Keywords: parasitic diseases; mtor pathway; mtor; pathway parasitic ... See more keywords
PI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05458-8
Abstract: Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance, there is no study investigating the role of the… read more here.
Keywords: mtor pathway; pathway autophagy; pi3k akt; metastasis ... See more keywords
PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Immunologic Research"
DOI: 10.1007/s12026-022-09268-x
Abstract: Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A single-stranded RNA virus from a β-Coronaviridae family causes acute clinical manifestations. Its high death rate and severe… read more here.
Keywords: sars cov; mtor pathway; therapy; anti sars ... See more keywords