Electrospun Poly‐l‐Lactic Acid Membranes Promote M2 Macrophage Polarization by Regulating the PCK2/AMPK/mTOR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400481
Abstract: Electrospun membranes are widely used in tissue engineering. Regretfully, there is limited research on how its morphological characteristics precisely regulate macrophage activation and immune response. Therefore, electrospun poly‐l‐lactic acid (PLLA) membranes with different alignments (align… read more here.
Keywords: mtor signaling; macrophage; electrospun poly; macrophage polarization ... See more keywords
Anti‐Apoptotic Efficacies of Iron Nanoparticles Green‐Formulated by Syzygium aromaticum Leaf Extract on NCI‐H661 Human Lung Adenocarcinoma Cell Line and Following the PI3K/AKT/mTOR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.70214
Abstract: The overstimulation of the mechanistic target of the rapamycin (mTOR) signaling pathway is important for regulating cellular growth and proliferation and is frequently seen in different types of cancer. Recently, metallic nanoparticles have been used… read more here.
Keywords: mtor signaling; iron; iron nanoparticles; nci h661 ... See more keywords
LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
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DOI: 10.1002/cam4.2165
Abstract: Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated… read more here.
Keywords: gastric cancer; mtor signaling; pi3k akt; signaling pathway ... See more keywords
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy
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DOI: 10.1002/cbin.11874
Abstract: In previous studies, we found that dynorphin exerts antiepileptic effect by activating the kappa opioid receptor (KOR). However, the role of neuronal autophagy in dynorphin/KOR‐mediated antiepileptic is still unclear. This study aimed to investigate the… read more here.
Keywords: seizure; signaling pathway; mtor signaling; epilepsy ... See more keywords
Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis
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DOI: 10.1002/cbin.12231
Abstract: This study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified… read more here.
Keywords: mtor signaling; breast cancer; pathway; mtor ... See more keywords
Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory subunit 2
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21978
Abstract: Replication protein A 3 (RPA3) is a significant component of replication protein A and has been documented to function as an oncogene in several types of cancers. However, the role and underlying mechanism of RPA3… read more here.
Keywords: cell; mtor signaling; akt mtor; cisplatin sensitivity ... See more keywords
mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30229
Abstract: Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought… read more here.
Keywords: like cells; mtor signaling; mtor; signaling like ... See more keywords
Effect of microRNA-145 on proliferation and apoptosis of human non-small cell lung cancer A549 cells by regulating mTOR signaling pathway.
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DOI: 10.1002/jcb.26629
Abstract: Our study aims to explore the impact of microRNA-145 (miR-145) on proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells by modulating mTOR signaling pathway. Paired NSCLC and adjacent normal tissues were obtained from… read more here.
Keywords: mir 145; mtor signaling; proliferation; signaling pathway ... See more keywords
Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28401
Abstract: The mammalian target of rapamycin (mTOR) is a large Ser/Thr protein kinase that belongs to the phosphoinositide 3‐kinase (PI3K) family and mediates various physiological and pathological processes, especially cell proliferation, protein synthesis, autophagy, and cancer… read more here.
Keywords: emerging roles; mtor signaling; regulating mtor; micrornas regulating ... See more keywords
Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives
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DOI: 10.1002/jcp.26276
Abstract: Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of… read more here.
Keywords: mtor signaling; pharmacological inhibitors; potency mtor; mtor ... See more keywords
Effects of mTOR/NF‐κB signaling pathway and high thoracic epidural anesthesia on myocardial ischemia‐reperfusion injury via autophagy in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26320
Abstract: We investigated the role of mammalian target of rapamycin/nuclear factor‐kappa B (mTOR/NF‐κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia‐reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was… read more here.
Keywords: thoracic epidural; high thoracic; pathway high; mtor signaling ... See more keywords