LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
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DOI: 10.1002/cam4.2165
Abstract: Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated… read more here.
Keywords: gastric cancer; mtor signaling; pi3k akt; signaling pathway ... See more keywords
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy
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DOI: 10.1002/cbin.11874
Abstract: In previous studies, we found that dynorphin exerts antiepileptic effect by activating the kappa opioid receptor (KOR). However, the role of neuronal autophagy in dynorphin/KOR‐mediated antiepileptic is still unclear. This study aimed to investigate the… read more here.
Keywords: seizure; signaling pathway; mtor signaling; epilepsy ... See more keywords
Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory subunit 2
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DOI: 10.1002/ddr.21978
Abstract: Replication protein A 3 (RPA3) is a significant component of replication protein A and has been documented to function as an oncogene in several types of cancers. However, the role and underlying mechanism of RPA3… read more here.
Keywords: cell; mtor signaling; akt mtor; cisplatin sensitivity ... See more keywords
mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice
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DOI: 10.1002/hep.30229
Abstract: Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought… read more here.
Keywords: like cells; mtor signaling; mtor; signaling like ... See more keywords
Effect of microRNA-145 on proliferation and apoptosis of human non-small cell lung cancer A549 cells by regulating mTOR signaling pathway.
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DOI: 10.1002/jcb.26629
Abstract: Our study aims to explore the impact of microRNA-145 (miR-145) on proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells by modulating mTOR signaling pathway. Paired NSCLC and adjacent normal tissues were obtained from… read more here.
Keywords: mir 145; mtor signaling; proliferation; signaling pathway ... See more keywords
Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis
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DOI: 10.1002/jcb.28401
Abstract: The mammalian target of rapamycin (mTOR) is a large Ser/Thr protein kinase that belongs to the phosphoinositide 3‐kinase (PI3K) family and mediates various physiological and pathological processes, especially cell proliferation, protein synthesis, autophagy, and cancer… read more here.
Keywords: emerging roles; mtor signaling; regulating mtor; micrornas regulating ... See more keywords
Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives
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DOI: 10.1002/jcp.26276
Abstract: Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of… read more here.
Keywords: mtor signaling; pharmacological inhibitors; potency mtor; mtor ... See more keywords
Effects of mTOR/NF‐κB signaling pathway and high thoracic epidural anesthesia on myocardial ischemia‐reperfusion injury via autophagy in rats
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DOI: 10.1002/jcp.26320
Abstract: We investigated the role of mammalian target of rapamycin/nuclear factor‐kappa B (mTOR/NF‐κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia‐reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was… read more here.
Keywords: thoracic epidural; high thoracic; pathway high; mtor signaling ... See more keywords
Overexpression of LINC00037 represses cervical cancer progression by activating mTOR signaling pathway
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DOI: 10.1002/jcp.28012
Abstract: Long non‐coding RNAs have been reported to play crucial roles in tumorigenesis including cervical cancer. LINC00037 has been identified as a significant regulator in several cancers. Our study was aimed to investigate the function of… read more here.
Keywords: linc00037; mtor signaling; cervical cancer; cancer progression ... See more keywords
Silencing of RHEB inhibits cell proliferation and promotes apoptosis in colorectal cancer cells via inhibition of the mTOR signaling pathway
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DOI: 10.1002/jcp.28984
Abstract: Colorectal cancer (CRC) is commonly known as one of the most prominent reasons for cancer‐related death in China. Ras homolog enriched in brain (RHEB) and the mammalian target activity of rapamycin (mTOR) signaling pathway were… read more here.
Keywords: cell proliferation; rheb; mtor signaling; mtor ... See more keywords
miR‐885 mediated cardioprotection against hypoxia/reoxygenation‐induced apoptosis in human cardiomyocytes via inhibition of PTEN and BCL2L11 and modulation of AKT/mTOR signaling
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DOI: 10.1002/jcp.29460
Abstract: Ischemia/reperfusion (I/R) injury could cause the enhanced cell apoptosis of cardiomyocytes, which is one of key contributors for the development of ischemic heart disease. Recent studies emphasized the role of microRNAs (miRNAs) in regulating cardiomyocyte… read more here.
Keywords: human cardiomyocytes; apoptosis; mtor signaling; mir 885 ... See more keywords